疏血通对慢性肺源性心脏病急性加重期患者红细胞的几何形状的定量的影响  

The Quantitative Influence of Shuxuetong on the Geometric Shape of Erythrocyte from the Acute Phase Patients with Chronic Pulmonary Heart Disease

作　　者：张燕[1] 黄勇[1] 吴泽志[2] 

机构地区：[1]重庆市中山医院呼吸内科,重庆400013 [2]重庆大学生物工程学院生物流变科学与技术教育部重点实验室,重庆400044

出　　处：《中国医学物理学杂志》2011年第6期3064-3066,3076,共4页Chinese Journal of Medical Physics

摘　　要：目的:探讨慢性肺源性心脏病(简称肺心病)急性加重期患者用疏血通前后红细胞几何形状的定量的改变。方法:采用微管吸吮技术分别测定40例慢性肺心病急性加重期患者用药前后周围血红细胞的表面积/体积,球度指数。结果:慢性肺心病患者急性期与正常对照相比红细胞表面积/体积降低,而球度指数显著增高。在一定浓度的疏血通作用后,红细胞的表面积/体积的比值(S/V)显著增高,球度指数显著降低。结论:一定浓度疏血通可降低肺心病急性期患者红细胞的球度指数,这为临床上在肺心病的综合治疗中包括改善红细胞变形性的药物或措施提供了实验依据。Objective: To compare the quantitative changes of the geometric shape of erythrocyte from the acute phase patients with chronic pulmonary heart disease between before and add Shuxuetong.Methods: In the venous blood 40 acute phase patients with chronic pulmonary heart disease between before and add drug,the ratio of erythrocyte surface/volume and sphericity index were determined using micropipette aspiration technique.Results: The acute phase patients with chronic pulmonary heart diseases were in contrast to normal human,the erythrocyte surface/volume ratio significantly lower,while sphericity index was significantly increased.In a certain concentration of Shuxuetong role,the red blood cell surface area / volume ratio(S / V) significantly increased,sphericity index was significantly lower.Conclusions: Shuxuetong of constant concentration can cause the decrease of the spherical indexes of erythrocytes in acute phase patients with chronic pulmonary heart disease.The study offers experimental evidences that the comprehensive treatment of pulmonary heart disease should involve the drug or measure to improve the erythrocyte deformability.

关 键 词：慢性肺源性心脏病 红细胞 几何形状 疏血通 

分 类 号：R312[医药卫生—基础医学]