56例SARS家庭聚集性发病患者的临床分析  

Clinical analysis of 56 patiens with critical severe acute respiratory syndrome in Beijing area

作　　者：阴赪宏[1] 王超[1] 文艳[1] 汤哲[2] 张淑文[1] 王宝恩[1] 

机构地区：[1]首都医科大学附属北京友谊医院,北京100050 [2]首都医科大学宣武医院,北京100053

出　　处：《感染．炎症．修复》2005年第3期131-134,共4页Infection Inflammation Repair

基　　金：北京市科技计划重大项目(No H020920050230)

摘　　要：目的：分析严重急性呼吸综合征(SARS)患者的临床特点。方法：回顾性分析56例家庭聚集发病SARS患者的临床资料。结果：SARS病情轻重分型无性别差异,60岁及以上患者、有慢性病史患者预后较差。其主要症状为发热、咳嗽、气短、胸闷、乏力、呼吸困难等；再次发热、呼吸困难以及LDH、CK-MB、HBDH、血糖、BUN、Cre升高、K、T细胞亚群、SaO_2、SpO_2降低与预后相关；X线胸片显示的肺病变、肺叶受损、肺受损面积更大,病情严重。SARS可伴有多种并发症,尤其合并有ARDS、休克、肾衰、多脏器衰竭者病死率明显增高。结论：SARS以呼吸道症状为主,淋巴细胞计数、T细胞亚群、血气分析、X线胸片等均有一定的改变,且以并发ARDS、休克及多脏器衰竭者病死率明显增高。Objective:To investigate the clinical characteristics of critical severe acute respiratory syndrome. Methods:The clinical data of 56 patients with critical SARS in Beijing were study retrospectively.Results:There was no significant difference in patients' condition between the male and the female.The prognosis of the patients over 60 years of age with history of chronic disease was poor.The main symptoms were fever,cough,shortenss of breath and difficulty in breathing.Recurrent fever,difficulty in breathing,LDH,CK-MB,HBDH,blood glu- cose,BUN,K,SaO_2,SpO_2 and subsets of T lymphocyte showed correlations with the prognosis.If X-ray chest radiography showed that the area of the injured lung was extensive,the patient's condition was seeious.Many complications could occur in SARS,especially when ARDS,shock,renal failure,the morbidity was increased. Conclusion:The symptoms of SARS mainly involved the respiratory tract.There were changes in lymphocyte count,subsets of T lymphocyte,arterial blood gas,and chest radiography in SARS.SARS when complicated by ARDS,shock and organ failure,the mortality would be increased.

关 键 词：严重急性呼吸综合征(SARS) 家庭聚集性 临床特征 

分 类 号：R51[医药卫生—内科学]