(R)-2-羟基-4-苯基丁酸乙酯合成综述  

Research on the synthesis of the Ethyl (R)-2-Hydroxy-4-Phenylbutyrate

作　　者：陈毛[1,2] 袁芳爱[1,2] 韦志明 孙果宋 陈小鹏 

机构地区：[1]广西大学化学化工学院,广西南宁530004 [2]广西化工研究院,广西南宁530001

出　　处：《化工中间体》2011年第3期1-4,共4页

摘　　要：(R)-2-羟基-4-苯基丁酸乙酯(R-HPBE)是合成血管紧张素转化酶抑制剂类抗高血压和充血性心力衰竭药物的重要手性中间体,综述了该化合物的合成方法并简述了应用前景。TEthyl (R)-2-hydroxy-4-phenylbutyrate was an important chiral intermediate for the synthesis of angiotensin converting enzyme inhibitor(ACEI),which were widely used to treat Lhe hypertension and congestive heart failure.The synthetic methods and prospects of Ethyl(R)-2-hydroxy-4-phenylbutyrate were reviewed.

关 键 词：(R)-2-羟基-4-苯基丁酸乙酯 综述 药物中间体 不对称合成 

分 类 号：TQ2[化学工程—有机化工]