慢性肝病患者血清总胆汁酸水平与肝组织炎症分级的量化关系研究  

correlation of serum total bile acid levels with liver tissue inflammation grade in chronic liver diseases

作　　者：丁贤君[1] 李世波[1] 黎运呈[1] 杨喆娟[1] 李绍佐[1] 刘华生[1] 林志益[1] 黄建荣[2] 

机构地区：[1]316000,浙江省舟山医院感染性疾病科 [2]浙江大学医学院附属第一医院感染病科

出　　处：《中华临床感染病杂志》2011年第6期-,共3页Chinese Journal of Clinical Infectious Diseases

摘　　要：目的 研究血清总胆汁酸(tba)水平与慢性肝病患者肝组织炎症分级间的量化关系.方法 用循环酶法检测172例各类慢性肝病患者血清tba水平,并进行肝组织病理活检,以确定炎症分级.采用spss12.0软件包分析tba与肝组织炎症分级之间的量化对应关系.结果 血清tba水平与肝组织炎症分级呈正相关(r=0.275,p＜0.01)；当tba达到20 μmol/l时,肝组织炎症分级达到g2水平.结论 血清tba水平在评估慢性肝病患者肝组织炎症分级方面具有重要意义. abstract： objective to investigate the correlation of serum total bile acid (tba) levels with the inflammation grades of liver tissue in chronic liver diseases.methods cyclophorase assay was used to detect the serum tba levels in 172 patients with various chronic liver diseases,and the inflammation grades of liver tissue were determined by liver biopsy.the correlation between serum tba levels and the inflammation grades of liver tissue was evaluated using spss 12.0 software.results serum tba level was positively correlated with the inflammation grade of liver tissue ( r =0.275,p ＜ 0.01 ).the inflammation grade reached g2 when serum tba was 20 μmol/l.conclusion serum tba level may be useful for evaluating the inflammation grade of liver tissue in chronic liver diseases.Objective To investigate the correlation of serum total bile acid (TBA) levels with the inflammation grades of liver tissue in chronic liver diseases.Methods Cyclophorase assay was used to detect the serum TBA levels in 172 patients with various chronic liver diseases,and the inflammation grades of liver tissue were determined by liver biopsy.The correlation between serum TBA levels and the inflammation grades of liver tissue was evaluated using SPSS 12.0 software.Results Serum TBA level was positively correlated with the inflammation grade of liver tissue ( r =0.275,P ＜ 0.01 ).The inflammation grade reached G2 when serum TBA was 20 μmol/L.Conclusion Serum TBA level may be useful for evaluating the inflammation grade of liver tissue in chronic liver diseases.

关 键 词：胆汁酸类和盐类 炎症 慢性肝病 

分 类 号：R512.62[医药卫生—内科学]