民航飞行员胱氨酸蛋白酶抑制剂c水平及其与血糖血脂关系的研究  

survey on the cystatin c level in civil pilots and its influence to blood glucose and lipid profile

作　　者：鲁炳怀[1] 朱凤霞[1] 贺亚杰[1] 史丽娜[1] 杨静[1] 

机构地区：[1]民航总医院检验科,北京100025

出　　处：《中华航空航天医学杂志》2009年第1期41-45,68,共5页Chinese Journal of Aerospace Medicine

摘　　要：目的 探讨民航飞行员的胱氨酸蛋白酶抑制剂c(cys c)水平及其与血糖血脂之间的关系. 方法 287名参加例行体检的男性飞行员(平均年龄为39.6±8.3岁),纳入本次研究,分别测定其空腹血糖(fbg)、总胆固醇(tc)、甘油三酯(tg)、高密度脂蛋白胆固醇(hdl-c)、低密度脂蛋白胆固醇(ldl-c)及cys c水平.对所得结果进行统计学分析. 结果 血脂代谢紊乱及空腹血糖受损的民航飞行员血清cys c水平较正常组显著增高(p<0.01);cys c水平与年龄无显著相关;随着脂代谢紊乱程度的增加,cys c呈显著增高趋势(f=5.80～11.26,p<0.01);pearson相关分析结果显示,cys c与tg、hdl、ldl及fbg存在显著相关(p<0.05);多因素回归分析显示,tg、hdl-c、ldl-c、fbg水平是cysc水平的显著影响因素(p<0.05). 结论 cys c水平与民航飞行员的糖、脂代谢紊乱等心血管疾病(cvd)危险因素显著相关,未来可能作为此类人群cvd发病危险评估及预警的重要指标,为飞行安全提供保障.objective to investigate the relationship between the levels of serum cystatin c (cys c) and fasting blood glucose (fbg) and lipid profiles in chinese civil pilot. methods two hundred and eight-seven pilots of civil aviation administration of china (male, 39.6±8.3 yrs) were involved in the study by taking the chance of their regular physical examination. the levels of fbg, lipid profiles and cys c were measured for final statistic analysis. results cys c levels of the pilots with dyslipidemia and injured glucose tolerance were significantly higher than that in normal group (p ～0.01). cys c level was insignificantly correlated with age. furthermore cys c showed an increasing tendency with the deterioration of lipid metabolism (f= 5.80-11.26, p< 0.01). the multiple linear regression analysis showed that triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and fbg were the significant influence factors against cys c. conclusions there is a significant correlation between cys c level and the risk factors of cardiovascular disease. therefore it might be taken as a potential predictive marker for judging cardiovascular events of pilot.

关 键 词：胱氨酸蛋白酶抑制剂 血脂异常 高血糖症 

分 类 号：R854[医药卫生—航空、航天与航海医学]