磺丁基醚-β-环糊精对吲哚美辛的包合作用研究  

Study on indometacin-sulfobutylether-β-cyclodextrin inclusion compound

作　　者：田宝勇[1] 刘英华[1] 齐晓丹[2] 杜秀芳[2] 王伟[2] 王清君[2] 

机构地区：[1]河北科技大学河北省分析测试研究中心,河北石家庄050018 [2]河北医科大学药学院,河北石家庄050017

出　　处：《河北科技大学学报》2012年第2期113-114,118,共3页Journal of Hebei University of Science and Technology

基　　金：河北省自然科学基金青年科学基金资助项目(C2010000488)

摘　　要：分别采用饱和水溶液法、研磨法以及冷冻干燥法制备吲哚美辛环糊精包合物,采用差示扫描量热法验证包合物的形成,用紫外分光光度法测量包合物中吲哚美辛药物的含量,计算包合率。结果表明,用研磨法制备的包合物包合率最高,高达61.0%,差示扫描量热图谱说明磺丁基醚-β-环糊精与吲哚美辛形成了包合物。采用研磨法制备磺丁基醚-β-环糊精包合物时能给予较高的能量,可以克服磺丁基醚-β-环糊精分子的空间位阻,使药物分子更容易进入主体分子空腔内,得到较高的包合率。The inclusion compound of indomethacin and SEB7-β-CD were prepared by saturated solution method,grinding method and freeze-dried method.The inclusion compound was identified by differential scanning calorimetric method.The contents of indometacin and inclusion rate were determined by the ultraviolet spectrometry(UV).Encapsulation efficiency of the SBE-β-CD inclusion compound prepared by grinding method can reach 61.0%.And the preparation of inclusion compound by grinding method makes drug molecules overcome the steric hindrance of the SBE-β-CD and enter the cavity of host molecules,so as to improve the inclusion rate.

关 键 词：吲哚美辛 磺丁基醚-Β-环糊精 包合物 

分 类 号：TQ46[化学工程—制药化工]