骨组织再生策略的思考及膜性负压假说  

Strategy of bone regeneration and negative membrane theory

作　　者：邱裕生[1] 张银刚[1] 

机构地区：[1]西安交通大学医学院第一附属医院骨科,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2011年第6期659-663,共5页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：国家自然科学基金资助项目(No.30973063);陕西省科技攻关项目(No.2008K11-02)~~

摘　　要：骨组织属缓慢再生组织,如何缩短骨折愈合时间,如何提高骨修复障碍如骨缺损、骨不连、骨坏死的治愈率,一直是骨科临床研究的热点,也是临床治疗中的难题之一。在隔膜技术引导骨组织再生和负压技术促进软组织再生技术的基础上,结合作者负压技术对骨髓间充质干细胞生物学特性影响及负压对兔颅骨缺损的修复的研究,提出膜性负压技术诱导骨组织再生的新理论。本文就此新理念的提出的背景、机制、应用前景作一阐述。Regeneration of bone tissues is slow.How to shorten the healing time and improve the repair of bone disorders,such as bone defect,nonunion and osteonecrosis,has been a hot issue in orthopedic clinical research and a difficult problem in clinical treatment.Based on membrane-guided bone regeneration and vacuum technology improving soft tissue regeneration,and combining our negative pressure study on the biological characteristics of mesenchymal stem cells and on the repair of skull defects of rabbits,we proposed the new theory of membranous negative pressure technology inducing bone regeneration.This paper explains this new concept and its context,mechanism,application prospective as well as the future development.

关 键 词：骨不连 骨坏死 隔膜技术 负压技术 

分 类 号：R687[医药卫生—骨科学]