蛋白聚糖与软骨结构、功能及骨关节病的关系  

Relationship of proteoglycan with the structure and function of cartilage and osteoarthropathy

作　　者：曹峻岭[1] 

机构地区：[1]西安交通大学医学院地方病研究所教育部环境与疾病相关基因重点实验室卫生部微量元素与地方病重点实验室,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2012年第2期131-136,共6页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：国家自然科学基金资助项目(No.31070725;30872187;30471499;30170831)~~

摘　　要：蛋白聚糖是一类由核心蛋白与1条或多条共价连接的氨基聚糖所组成的糖复合物,是细胞膜、基底膜、特别是细胞外基质的重要组成成份,与组织细胞的结构和功能息息相关。随着科学研究的发展,人们逐渐认识到蛋白聚糖代谢与骨软骨发育和退变、神经组织的发育和退变、心血管疾病和肿瘤的发生发展关系密切。本文仅对蛋白聚糖代谢与软骨结构和功能及骨关节病发病机制的研究进行探讨。Proteoglycan,a type of glycoconjugate,consists of a core protein and one or more covalently attached glycosaminoglycan chains.It is an important component of cell membrane,fundus membrane,especially in extracellular matrix.It is also related to the histological structure and function of cells.With the advances in scientific research,proteoglycan metabolism has been found to have association with the growth and degradation of bone,cartilage and neural tissues.Recent studies also indicate that it is related to the development of cardiovascular diseases and tumors.The relationship of proteoglycan metabolism with the structure and function of cartilage and pathogenesis of osteoarthropathy will be discussed in this paper.

关 键 词：蛋白聚糖 硫酸化修饰 软骨 细胞外基质 骨关节病 大骨节病 

分 类 号：R684.1[医药卫生—骨科学]