益肾保真方对慢性肾功能衰竭大鼠营养不良的干预作用  

Yishenbaozhen decoction's intervening effect on malnutrition in rats with chronic renal failure

作　　者：张晓菊[1] 周冬枝[1] 夏欣欣[1] 吴琼[1] 张海燕[1] 

机构地区：[1]西安交通大学医学院第一附属医院中医科,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2012年第2期237-240,共4页Journal of Xi’an Jiaotong University（Medical Sciences）

摘　　要：目的探讨益肾保真方对慢性肾功能衰竭(CRF)营养不良的干预作用。方法采用二步5/6肾切除法复制大鼠慢性CRF模型,随机分为正常组、模型组、尿毒清组(2.5g/kg.d)、开同组(0.78g/kg.d)及益肾保真方高剂量组(46.5g/kg.d)、低剂量组(15.6g/kg.d)。给药6周,观察大鼠摄食量、体重,检测血尿素氮(BUN)、血肌酐(Scr)、尿蛋白定量(24hUprV)、白蛋白(ALB)及胆固醇(Chol)变化。结果模型组大鼠BUN、Scr、24hUprV及Chol较正常组显著升高,摄食量、体重及血清ALB水平显著降低。与模型组比较,益肾保真方组的血BUN、Scr、24hUprV及Chol显著降低(P<0.01),摄食量、体重及血清ALB水平显著升高(P<0.01)。结论益肾保真方对CRF大鼠营养不良有良好的干预作用。Objective To explore the intervening effect of Yishenbaozhen decoction(YSBZD) on malnutrition in rats with chronic renal failure(CRF). Methods We reproduced the rat model of chronic renal failure with the method of the two-step 5/6 nephrectomy.All rats were divided into six groups: normal group,model group,ketosteril group,Niaoduqing group as well as YSBZD high-(46.5 g/kg·d) and low-dose(15.6 g/kg·d) groups.After six-week treatment,we measured food intake and body weight,detected blood urea nitrogen(BUN),serum creatinine(Scr),24 h urine protein(24 hUprV),albumin(ALB) and cholesterol(Chol). Results BUN,Scr,24 hUprV and Chol were remarkably higher in model group than in normal group.Food intake,weight and ALB decreased remarkably.Compared with model group,YSBZD group had notably decreased BUN,Scr,24 hUprV and Chol(P<0.01),but remarkably increased food intake,body weight and ALB(P<0.01). Conclusion YSBZD can interfere with the process of malnutrition in CRF rats.

关 键 词：益肾保真方 慢性肾功能衰竭 营养不良 大鼠 血尿素氮 血肌酐 尿蛋白定量 白蛋白 胆固醇 

分 类 号：R692[医药卫生—泌尿科学]