檀香不同部位提取物对豚鼠离体肠平滑肌功能的影响  

Effects of different sandalwood extracts on isolated ileum smooth muscle of guinea pigs

作　　者：刘红艳[1,2] 郭建生[1,2,3] 王小娟[4] 陈君[1,2] 聂子文[1,2] 张猛[1,2] 

机构地区：[1]湖南中医药大学药学院 [2]湖南省教育厅中药现代化研究重点实验室 [3]国家中药管理局药性与药效研究三级实验室 [4]湖南中医药大学附属第一医院,湖南长沙410208

出　　处：《西安交通大学学报（医学版）》2012年第2期241-244,共4页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：国家科技部973资助项目:中药药性理论相关基础问题研究(No.2007CB512603);湖南省中药重点学科基金资助项目~~

摘　　要：目的对檀香不同提取方法所得到的不同提取物进行离体实验研究,为初步阐明辛能行气的现代化表征提供药理学实验依据。方法采用离体方法观察檀香不同提取物对豚鼠离体回肠运动功能的影响。结果檀香常规水煎液、挥发油及醇提液对正常状态下豚鼠离体肠有抑制作用,檀香水提液对其有兴奋作用;檀香4种不同提取物对乙酰胆碱造成的痉挛状态下豚鼠离体肠有抑制作用;檀香水提液、挥发油及醇提液对阿托品造成的松弛状态下豚鼠离体肠有抑制作用,常规水煎液对其无作用。结论檀香对豚鼠离体肠自主运动有双向调节作用,对乙酰胆碱(Ach)造成的痉挛状态有拮抗作用,对阿托品造成的松弛状态有协同作用。Objective To conduct an in vitro experiment in different sandalwood extracts obtained with different methods so as to provide pharmacological experiment basis for clarifying the modern characterization that acrid taste can promote circulation of qi. Methods Effects of different sandalwood extracts on the motor function of isolated guinea pig ileum were observed in vitro. Results Conventional sandalwood water-frying liquid,volatile oil and alcohol extract fluid inhibited isolated guinea pig intestine in normal conditions.In contrast,sandalwood water extract fluid could stimulate isolated guinea pig intestine in normal conditions.The four different sandalwood extracts inhibited isolated guinea pig ileum with acetylcholine-caused spasms;sandalwood water extract liquid,volatile oil and alcohol extract liquid inhibited isolated guinea pig ileum with atropine-caused flabby condition,whereas conventional water-frying liquid had no such effect. Conclusion Sandalwood can adjust in two ways the autonomous motion of isolated guinea pig intestine,and exerts an antagonistic action on acetylcholine(Ach)-caused spasm and a synergistic action on atropine-caused flabby condition.

关 键 词：檀香 豚鼠离体肠 乙酰胆碱 阿托品 回肠运动 

分 类 号：R285.5[医药卫生—中药学]