甘油磷脂酰胆碱的分离纯化研究  

Separation and Purification of Glycerophosphocholine(GPC)

作　　者：周丽[1] 王兴国[1] 张康逸[1] 刘元法[1] 

机构地区：[1]江南大学食品学院,江苏无锡214122

出　　处：《食品与生物技术学报》2012年第1期67-70,共4页Journal of Food Science and Biotechnology

基　　金：国家"十二五"科技支撑计划重点项目(2011BAD02B04)

摘　　要：甘油磷脂酰胆碱(GPC)是磷脂酰胆碱(PC)分子上的两个脂肪酰基完全被水解掉的产物。为得到较纯的甘油磷酸胆碱,作者通过粉末磷脂水解获得GPC混合物,然后从3种离子交换树脂中筛选出D113树脂作为分离甘油磷酸胆碱的主要树脂,研究了其对甘油磷酸胆碱的吸附作用与解吸过程,解吸液通过特定的阴离子交换树脂的进一步纯化,所得产品经过HPLC分析,GPC的干基质量分数为97.11%。Glycerophosphocholine(GPC) is obtained by completely deacylated from phosphacholine(PC).In order to obtain the more pure product,a process for separating glycerophosphocholine(GPC) from raw deacylated mixtures of crude soy lecithin is was developed in this manuscript..Then three resins were selected and compared,of them,D113 is selected to more detailed study its adsorption and desorption process.The elution was then eluted on a strong basic resin in OH form.After concerntration,the purity of GPC product is up to 97.11% on dry basis by HPLC analysis.

关 键 词：甘油磷酸胆碱 离子交换 分离 

分 类 号：TQ464.4[化学工程—制药化工]