腰果过敏原Ana o 2结构及抗原表位预测  

Prediction of the Structure and Antigenic Epitopes of Cashew Allergen Ana o 2

作　　者：朱倩倩[1] 吴序栎[2] 肖杰[1] 成小娟[1] lujun 刘志刚[2] 徐宏[1] 

机构地区：[1]深圳大学化学与化工学院,广东深圳,518060 [2]深圳大学医学院,广东深圳,518060 [3]School of Biological Science, university of auckland, auckland, new zealand

出　　处：《食品与生物技术学报》2012年第2期141-145,共5页Journal of Food Science and Biotechnology

基　　金：国家自然科学基金项目(30871752,30570421);The International Science and Technology(ISAT)Linkages Fund,Royal Soci-ety of New Zealand(ISATB09-33);广东省科技重点专项(2003A3080502);教育部留学回国人员科研启动基金资助项目

摘　　要：腰果是引起人们过敏的主要食物之一。作者采用生物信息学方法,通过Pubmed网络服务器、生物信息分析软件SOPMA、swiss-model网络服务器、DNAStar生物分析软件等对腰果主要过敏原Ana o 2的结构和抗原表位进行预测,分析Ana o 2蛋白的抗原表位可能是108-111,181-186,217-218,234-238,244-255,283-287。这为腰果过敏原的进一步研究提供理论参考,并对开发低过敏腰果制品提供帮助。Cashew is one of the foods which can cause people allergic.In this manuscript,the sequence characteristics,secondary and tertiary structure,antigenic epitopes,hydrophobicities and surface accessibility,flexibility of allergen Ana o 2 from cashew were predicted and analyzed by using bioinformatics methods,such as Pubmed,SOPMA,swiss-model and DNAStar.Results demonstrated that the epitopes of Ana o 2 are probably at 108-111,181-186,217-218,234-238,244-255,283-287.These should be helpful for the further research of cashew allergen and be useful to develop of low sensitization cashew products.

关 键 词：腰果 Anao2 结构 抗原表位 

分 类 号：R392[医药卫生—免疫学]