Spectrofluorimetric method for determination of some angiotensin II receptor antagonists  

作　　者：Salwa R. El-Shaboury Samiha A. Hussein Niveen A. Mohamed Mohamed M. El-Sutohy 

机构地区：[1]Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University [2]Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Al-Azhar University

出　　处：《Journal of Pharmaceutical Analysis》2012年第1期12-18,共7页药物分析学报（英文版）

摘　　要：A simple, rapid, accurate and highly sensitive spectrofluorimetric method has been developed for determination of some angiotensin II receptor antagonists (AIIRA’s), namely Losartan potassium (Los-K), Irbesartan (Irb), Valsartan (Val) and Candesartan cilexetil (Cand) in pure forms as well as in their pharmaceutical dosage forms. All the variables affecting the relative fluorescence intensity (RFI) were studied and optimized. Under the optimum conditions, linear relationships with good correlation coefflcients (0.9982–0.9991) were obtained over the concentration range from 0.006 mg/mL to 1.7 mg/mL. Good accuracy and precision were successfully obtained for the analysis of tablets containing each drug alone or combined with hydrochlorothiazide (HCTZ) without interferences from the co-formulated HCTZ or the additives commonly present in tablets.A simple, rapid, accurate and highly sensitive spectrofluorimetric method has been developed for determination of some angiotensin II receptor antagonists (AIIRA’s), namely Losartan potassium (Los-K), Irbesartan (Irb), Valsartan (Val) and Candesartan cilexetil (Cand) in pure forms as well as in their pharmaceutical dosage forms. All the variables affecting the relative fluorescence intensity (RFI) were studied and optimized. Under the optimum conditions, linear relationships with good correlation coefflcients (0.9982–0.9991) were obtained over the concentration range from 0.006 mg/mL to 1.7 mg/mL. Good accuracy and precision were successfully obtained for the analysis of tablets containing each drug alone or combined with hydrochlorothiazide (HCTZ) without interferences from the co-formulated HCTZ or the additives commonly present in tablets.

关 键 词：Angiotensin II receptor antagonists SPECTROFLUORIMETRY DETERMINATION 

分 类 号：R96[医药卫生—药理学]