Validated spectrofluorimetric method for the determination of atorvastatin in pharmaceutical preparations  

作　　者：Mohie M.K.Sharaf El-Din Fathy M.M.Salama Mohamed W.I.Nassar Khalid A.M.Attia Mohamed M.Y.Kaddah 

机构地区：[1]Department of Analytical Chemistry,Faculty of Pharmacy,Mansoura University [2]Department of Analytical Chemistry,Faculty of Pharmacy,Al-Azhar University,Cairo,Egypt [3]Department of Analytical Chemistry,Faculty of Pharmacy,Mansoura University,Mansoura,Egypt

出　　处：《Journal of Pharmaceutical Analysis》2012年第3期200-205,共6页药物分析学报（英文版）

摘　　要：A rapid,sensitive and simple spectrofluorimetric method was developed for the estimation of atorvastatin.In this method,the native fluorescence characteristics of atorvastatin have been studied in both acidic and basic media.High sensitivity was obtained with 5% acetic acid at 389 nm using 276 nm for excitation.Regression analysis showed a good correlation coefficient(r=0.9995) between fluorescence intensity and concentration over the range of 1.5-4 mg/mL with detection limit of 0.012 mg/mL.The proposed method was successfully applied to the analysis of atorvastatin in pure and pharmaceutical dosage forms with average recovery of 100.2970.47%.The results were compared favorably with those of the reported method.A rapid,sensitive and simple spectrofluorimetric method was developed for the estimation of atorvastatin.In this method,the native fluorescence characteristics of atorvastatin have been studied in both acidic and basic media.High sensitivity was obtained with 5% acetic acid at 389 nm using 276 nm for excitation.Regression analysis showed a good correlation coefficient(r=0.9995) between fluorescence intensity and concentration over the range of 1.5-4 mg/mL with detection limit of 0.012 mg/mL.The proposed method was successfully applied to the analysis of atorvastatin in pure and pharmaceutical dosage forms with average recovery of 100.2970.47%.The results were compared favorably with those of the reported method.

关 键 词：SPECTROFLUORIMETRIC ATORVASTATIN Native fluorescence 

分 类 号：R943[医药卫生—药剂学]