Detection of captopril based on its enhanced resonance light scattering signals of fluorosurfactant-capped gold nanoparticles  

作　　者：Nan Zhang,Chao Lü State Key Laboratory of Chemical Resource Engineering,Beijing University of Chemical Technology,Beijing 100029,China. 

出　　处：《Journal of Pharmaceutical Analysis》2010年第2期71-76,82,共7页药物分析学报（英文版）

基　　金：supported by the National Natural Science Foundation of China (No.20975010)

摘　　要：In this study,based on its enhancement effect on resonance light scattering (RLS) of fluorosurfactant (FSN)-capped gold nanoparticles (GNPs),we reported a simple approach for the rapid sensing of captopril. Under optimum conditions,the lowest detectable concentration of captopril through this approach (S/N=3) was 0.01μg/mL. The calibration curve was linear over the range of 0.08-4.0μg/mL for the detection of captopril. The recoveries of captopril were found to fall in the range between 99% and 100%. We have validated the applicability of our method through the analyses of captopril in pharmaceutical formulations. Good agreements were obtained for the determination of captopril between the present approach and official method.In this study,based on its enhancement effect on resonance light scattering (RLS) of fluorosurfactant (FSN)-capped gold nanoparticles (GNPs),we reported a simple approach for the rapid sensing of captopril. Under optimum conditions,the lowest detectable concentration of captopril through this approach (S/N=3) was 0.01μg/mL. The calibration curve was linear over the range of 0.08-4.0μg/mL for the detection of captopril. The recoveries of captopril were found to fall in the range between 99% and 100%. We have validated the applicability of our method through the analyses of captopril in pharmaceutical formulations. Good agreements were obtained for the determination of captopril between the present approach and official method.

关 键 词：gold nanoparticles FLUOROSURFACTANT CAPTOPRIL resonance light scattering 

分 类 号：R927.2[医药卫生—药学]