含嘧啶杂环的二氯烯丙醚类衍生物的合成与杀虫活性研究  

Synthesis and Insecticidal Activity of Dichloroallyl Ether Derivatives Containing Pyrimidine Group

作　　者：韦天龙[1,2,3] 徐满才[1] 刘兴平[2,3] 裴晖[2,3] 左金江[1,2,3] 余一平[2,3,4] 项军[2,3] 林雪梅[2,3] 柳爱平[2,3] 

机构地区：[1]湖南师范大学化学化工学院,湖南长沙410081 [2]湖南化工研究院国家农药创制工程技术研究中心,湖南长沙410014 [3]农用化学品湖南省重点实验室,湖南长沙410014 [4]长沙理工大学化学与生物工程学院,湖南长沙410114

出　　处：《精细化工中间体》2012年第1期14-17,共4页Fine Chemical Intermediates

基　　金：国家重点基础研究发展计划(973)项目(2010CB126104);国家自然科学基金资助项目(20872033);"十二五"国家科技支撑计划课题(2011BAE06B01;2011BAE06B02);湖南省自然科学基金(11JJ2006;11JJ3022;10JJ3053);湖南省科技计划项目(2010FJ2003);湖南省科研条件创新专项资助(2010PT2058)

摘　　要：设计并合成了8个含嘧啶杂环的二氯烯丙醚类化合物。其化学结构经1H NMR、LC-MASS进行表征,测试了其生物活性,并探讨了结构与生物活性关系。初步生物活性测定表明:标题化合物具有很好的杀虫活性,在100 mg/L的剂量下,采用Potter喷雾法,化合物6a、6b、6c、6d和6e对粘虫有100%的活性;在500 mg/L浓度下,采用浸植株接虫法,化合物6a和6c对稻黑尾叶蝉的死亡率达到90%以上。Eight novel dichloroallyl ether derivatives containing pyrimidines were designed and synthesized.Their structures were confirmed by 1H NMR and LC-MS,and their biological activities were evaluated.The relationship between the structures and the biological activity was discussed.The preliminary bioassay results showed that the title compounds had good insecticidal activity.Compounds 6a,6b,6c,6d and 6e in Potter spray method exhibited 100% control against mythimna separata at 100 mg/L.Compounds 6a and 6c used in the plants by insect method showed more than 90% control against nephotettix cincticeps at 500 mg/L.

关 键 词：嘧啶二氯烯丙醚 合成 杀虫活性 

分 类 号：S482.3[农业科学—农药学]