新型邻甲酰胺基苯甲酰胺衍生物的合成与生物活性研究  

Synthesis and Biological Activities of Novel Anthranilic Diamide Derivatives

作　　者：唐明[1,2,3] 吴道新[1] 胡志彬[2,3] 高岗[2,3,4] 韩魁元[1,2,3] 任叶果[2,3] 裴晖[2,3] 黄路[2,3] 喻快[2,3] 柳爱平[2,3] 

机构地区：[1]长沙理工大学化学与生物工程学院,湖南长沙410114 [2]湖南化工研究院国家农药创制工程技术研究中心,湖南长沙410014 [3]农用化学品湖南省重点实验室,湖南长沙410014 [4]湖南师范大学化学化工学院,湖南长沙410081

出　　处：《精细化工中间体》2012年第1期28-33,共6页Fine Chemical Intermediates

基　　金：国家重点基础研究发展计划(973)项目(2010CB126104);国家自然科学基金资助项目(20872033);"十二五"国家科技支撑计划课题(2011BAE06B01);湖南省自然科学基金(11JJ2006;11JJ3022;10JJ3053);湖南省科技计划项目(2010FJ2003);湖南省科研条件创新专项(2010PT2058)

摘　　要：合成了9个新型邻甲酰胺基苯甲酰胺衍生物,其结构经1H NMR进行确证。初步杀虫、杀螨活性测试表明所合成的化合物在1 000 mg/L浓度下对磷翅目的粘虫(Mythimna separata)有100%的致死率。在500 mg/L浓度下,大多化合物对同翅目的蚕豆蚜(Aphis fabae)以及稻黑尾叶蝉(Nephotettix cincticeps)具有明显活性,如化合物3-溴-1-(3-氯-2-吡啶基)-N-[4-氯-2-甲基-6-[((3,3-二氯烯丙氧基)氨基)羰基]苯基]-1H-吡唑-5-甲酰胺(14c)对蚕豆蚜的致死率达到89.29%;化合物14b对叶蝉的致死率达到81.82%。在500 mg/L浓度下,所合成化合物对蜱螨目棉红蜘蛛(Tetranchus urticae)没有表现出明显活性。To search for compounds with unique biological activities,a series of novel anthranilic diamide derivatives were designed and synthesized,and their structures were characterized by 1H NMR spectroscopy.The results of bioassays indicated that all of the title compounds exhibited 100% insecticidal activities against lepidopte ranpests Mythimna separata at a concentration of 1 000 mg/L.Most of the compounds exhibited good insecticidal activities against Homopteran pests at a concentration of 500 mg/L.For example,14c showed 89.29% insecticidal activities against Aphis fabae,and 14b showed 81.82% insecticidal activities against Nephotettix cincticeps.All of the title compounds exhibited no acaricidal activities against mite at a concentration of 500 mg/L.

关 键 词：邻甲酰胺基苯甲酰胺衍生物 合成 杀虫活性 

分 类 号：S482.3[农业科学—农药学]