N-甲氧基邻氨基苯甲酰胺衍生物的合成与生物活性  

Synthesis and Bioactivity of N-Methoxyl-o-aminobenzamide Derivatives

作　　者：左文清[1,2,3] 吴道新[1] 柳爱平[2,3] 胡志彬[2,3] 高岗[2,3,4] 韩魁元[1,2,3] 任叶果[2,3] 裴晖[2,3] 胡礼[2,3] 喻快[2,3] 毛春晖[2,3] 

机构地区：[1]长沙理工大学化学与生物工程学院,湖南长沙410114 [2]湖南化工研究院 国家农药创制工程技术研究中心,湖南长沙410014 [3]农用化学品湖南省重点实验室,湖南长沙410014 [4]湖南师范大学化学化工学院,湖南长沙410081

出　　处：《精细化工中间体》2012年第2期9-13,共5页Fine Chemical Intermediates

基　　金：国家重点基础研究发展计划(973)项目(2010CB126104);"十二五"国家科技支撑计划课题(2011BAE06B01);湖南省自然科学基金(11JJ2006)

摘　　要：为了寻求广谱、高效、安全的鱼尼丁受体作用剂,设计并合成了9个邻氨基N-甲氧基苯甲酰胺类化合物。其结构经1H NMR、HPLC-Mass和IR分析确证。初步生物活性测试表明:目标化合物在100 mg/L浓度下对鳞翅目粘虫(Mythimna separata)有100%的致死率。在500 mg/L浓度下,大多化合物对同翅目的豆蚜(Aphis fabae)以及叶蝉(Nephotettix cincticeps)具有显著的活性,如化合物11a、11c、11e和11g对蚜虫的活性在90%以上,化合物11e和11i对叶蝉的活性达到了100%。在500 mg/L浓度下,目标化合物对螨虫红蜘蛛(Tetranchus urticae)没有表现出明显活性。To seek for broad spectra,high efficiency and safe pesticides which work on ryanodines receptor,nine novel N-methoxyl-o-aminobenzamide derivatives were designed and synthesized.Their structures were confirmed by 1H NMR.The preliminary bioactivity evaluation showed that the compounds had 100% insecticidal activities against lepidopte ranpests Mythimna separata at 100 mg/L.At 500 mg/L,most of the compounds exhibited good activities against Homopteran pests Aphis fabae and mite Nephotettix cincticeps.For example,compounds 11a,11c,11e and 11g showed more than 90% insecticidal activities against Aphis fabae;the compound 11e and 11i showed 100% insecticidal activities against Nephotettix cincticeps.All of the title compounds exhibited no acaricidal activities against mite at 500 mg/L.

关 键 词：N-甲氧基邻氨基苯甲酰胺 鱼尼丁受体作用剂 杀虫活性 

分 类 号：TQ453[化学工程—农药化工]