加减三甲散及其拆方对肝纤维化大鼠PⅢNP、HA的影响  

Effects of modified Sanjia Powder and Its sub-formulas on the PⅢNP and HA of rats with hepatic fibrosis

作　　者：乔胃娟[1] 杨宇[1] 周新颖[1] 袁建[1] 刘旺华[1] 闫颖[1] 

机构地区：[1]成都中医药大学,四川成都610075

出　　处：《中药与临床》2010年第3期34-35,共2页Pharmacy and Clinics of Chinese Materia Medica

基　　金：四川省科技计划项目(2008JY0084)

摘　　要：目的:通过观察加减三甲散及其拆方对肝纤维化大鼠血清Ⅲ型前胶原肽(PⅢNP)、血清透明质酸(HA)含量的影响,部分阐明本方及拆方治疗肝纤维化的机理。方法:用四氯化碳诱导造成大鼠肝纤维化模型,观察各组对大鼠血清PⅢNP、HA含量的影响。结果:加减三甲散组能显著降低PⅢNP与HA含量,与模型组比较,差异有高度统计学意义(P<0.01),去滋阴药组能降低HA的含量,与模型组比较,差异有统计学意义(P﹤0.05)。结论:加减三甲散及其拆方能够促进胶原降解,对实验性肝纤维化有一定治疗作用。Objective:To partly clarify the mechanism of modified Sanjia Powder and its Sub-Formulas on hepatic fibrosis by observing the effects on N-terminal Procollagen Ⅲ Propeptide(PⅢNP) and Hyaluronic Acid(HA) of rats with hepatic fibrosis.Method:The hepatic fibrosis model in rats was established by CCl4 administration.And the concentration of PⅢNP and HA in serum were tested.Result:The group of modified Sanjia Powder can decrease the level of PⅢNP and HA(P<0.01),and the group without Yin-enriching material can lower the level of HA(P<0.05) compared with blank group.Conclusion:Modified Sanjia Powder and its sub-formulas have the effects on experimental hepatic fibrosis by promoting collagen-degradation.

关 键 词：加减三甲散 滋阴 肝纤维化 Ⅲ型前胶原肽 血清透明质酸 

分 类 号：R285.5[医药卫生—中药学]