熏硫药材中二氧化硫残留在中药提取过程中的溶出率研究  

Study on dissolution rate of sulphur dioxide residue in sulphur fuming herbs by extraction

作　　者：陈曙[1] 万丽[1] 马熙[1] 黄珍[1] 李峻媛[1] 林芳[1] 

机构地区：[1]成都中医药大学药学院中药材标准化教育部重点实验室中药资源系统研究与开发利用省部共建国家重点实验室培育基地,四川成都610075

出　　处：《中药与临床》2010年第4期27-29,共3页Pharmacy and Clinics of Chinese Materia Medica

基　　金：四川省教育厅科技创新重大培育项目(批准号:09ZZ008)

摘　　要：目的:研究熏硫药材中二氧化硫残留在中药提取过程中的溶出情况。方法:采用煎煮、回流、渗漉和浸渍工艺对熏硫药材进行提取得到浸膏后,参考中国药典2010年版一部附录IXU项下的二氧化硫残留量测定法,对浸膏中的二氧化硫残留量进行测定,计算溶出率。结果:四种提取工艺所得浸膏中二氧化硫残留的溶出率均不到30%,其中以浸渍溶出率最高,煎煮溶出率最低,不同浓度的醇提溶出率不同。结论:熏硫药材中二氧化硫残留在中药提取过程中溶出率比较低,且不同提取工艺和不同浓度的醇提对二氧化硫残留的溶出率也不同。Objective:To study the influence of extraction technology on dissolution of SO2 residues in sulphur fuming medicinal herbs.Method:Extractum is extracted by water decoction,regurgitation,percolation and extraction.Then the sulfur dioxide residues in extractum were measured according to Chinese Pharmacopoeia,and the dissolution rate was calculated.Result:The dissolution rates of sulfur dioxide were below 30% in four extractum.The highest dissolution rate was found in ethanol immersion,and the lowest in water decoction.Different dissolution rate was found for different alcohol concentrations.Conclusion:Low SO2 residues dissolution is found in extraction of sulphur fuming medicinal herbs.The extraction methods and alcohol concentrations will influence the dissolution rate.

关 键 词：提取过程 熏硫药材 二氧化硫残留 溶出率 

分 类 号：R282.4[医药卫生—中药学]