葛根素对甲状腺素致心肌肥厚大鼠心脏形态及功能的影响  

Effects of puerarin on cardiac shape and function in myocardial hypertrophy induced by levothyoxine in rat

作　　者：曾佑琴[1] 孟亚鹏[1] 

机构地区：[1]成都中医药大学医学技术学院,四川成都610041

出　　处：《中药与临床》2010年第4期37-39,共3页Pharmacy and Clinics of Chinese Materia Medica

基　　金：成都中医药大学校基金项目(ZRYB200816)

摘　　要：目的:探讨葛根素(Puerarin,Pue)对L-甲状腺素(Levothyoxine,Lev)所致大鼠心肌肥厚的心脏形态和功能的影响。方法:SD大鼠注射L-甲状腺素建立心肌肥厚模型,Pue按100mg·kg-1灌胃给药,监测血压持续15天,检测大鼠心功能,取心肌组织测心肌胶原和Ca2+浓度。结果:Pue组显著降低L-甲状腺素模型大鼠血压,降低Ca2+浓度组织胶原含量。结论:葛根素对甲状腺素所致大鼠心肌肥厚有一定的抑制作用。Objective:To explore the effect of puerarin(Pue)on cardiac shape and function in myocardial hypertrophy(MH)induced by levothyoxine(Lev).Method:The MH model was established by hypodermic injection of levothyoxine in SD rats.Pue was given to rats orally(100mg·kg-1)for 10 days,and rat blood pressure was monitored.The rat cardiac function,collagen and Ca2+ concentration of cardiac cell were measured.Result:Compared with Lev group,Pue significantly decreased the blood pressure,collagen and Ca2+concentration.Conclusion:These results indicate that Pue has some certain function in inhibiting myocardial hypertrophy induced by Lev.

关 键 词：葛根素 L-甲状腺素 心肌肥厚:大鼠 

分 类 号：R285.5[医药卫生—中药学]