维持性血液透析患者乙型肝炎和丙型肝炎病毒感染临床调查分析  

Clinical investigation and analysis in maintenance hemodialysis patients with HBV and HCV infection

作　　者：汪虹伶 彭洪泉[1] 林婉萍[1] 颜雅怡 

机构地区：[1]澳门镜湖医院血液透析中心

出　　处：《中国血液净化》2012年第3期168-170,共3页Chinese Journal of Blood Purification

摘　　要：目的调查分析维持性血液透析患者乙型肝炎病毒(HBV)及丙型肝炎病毒(HCV)的感染情况。方法回顾性分析镜湖医院1985年2月～2010年12月期间维持性血液透析3个月以上患者的临床数据,调查分析肝炎病毒感染的情况。结果 1155例患者,HBV阳性总数83例(7.18%),其中原有感染阳性者77例(6.66%),透析后感染阳性者6例(0.57%);HCV阳性总数59例(5.10%),其中原有感染阳性者38例(3.29%),透析后感染阳性者21例(2.01%)。透析后感染率明显低于原有感染率(P<0.05)。透析后肝炎病毒感染,尤以HCV的感染多见,而HBV的感染则少见。原有感染组中,有7例HBV阳性者转阴,2例HCV的阳性者转阴。结论有效隔离,防止交叉感染,广泛使用促红细胞生成素,使用一次性透析器,血液透析肝炎病毒感染可以得到有效控制。Objective To analyze the maintenance hemodialysis patients complicated with hepatitis B virus(HBV) and hepatitis C virus(HCV) infection.Methods Retrospective analysis was used for maintenance hemodialysis patients and clinical data over three months in Kiang Wu Hospital from February 1985 to December 2010 were collected.Results Among the total 1155 cases,HBV-positive were 83 cases(7.18%),pre-dialysis HBV-positive were 77 cases(6.66%),6 cases(0.57%) were positive after dialysis.The total number of HCV-positive were 59 patients(5.10%).However,the HCV positive in pre-dialysis group was 38 cases(3.29%),21 patients(2.01%) were positive after dialysis.The post-dialysis infection prevalence was significantly lower than that in the pre-dialysis infection(P<0.05).Hepatitis virus infection in post-dialysis are common,particularly for HCV infection.As to HBV infection,it was uncommon to catch hepatitis B virus infection with hemodialysis.Among the whole infected group,there were seven cases of HBV-positive cases turning to negative,2 HCV-positive cases turning to negative.Conclusion With strict and effective separation measures,widespread use of erythropoietin,and the use of disposable dialyzers,HBV and HCV infection can be effectively controlled under hemodialysis setting.

关 键 词：血液透析 肝炎病毒 感染 

分 类 号：R318.16[医药卫生—生物医学工程]