阻塞性睡眠呼吸暂停综合征患者血浆血管内皮生长因子浓度测定(英文)  

Increased level of vascular endothelial growth factor in obstructive sleep apnea syndrome with severe nocturnal hypoxia

作　　者：王艳姣[1] 杨宇[1] 张湘瑜[1] 傅柳英[1] 

机构地区：[1]中南大学湘雅二医院老年内科,湖南长沙410011

出　　处：《中国现代医学杂志》2004年第13期45-48,共4页China Journal of Modern Medicine

基　　金：ThisworkwassupportedbygrantsfromHunanProvincialScienceandTechnologyBureau(03SSY3085)andCentralHealthCareCommittee(2002Xiang-A001)

摘　　要：目的探讨伴有不同程度夜间缺氧血症的阻塞性睡眠呼吸暂停综合征(Obstructive sleep apnea syndrome, OSAS)患者血浆血管内皮生因子(Vascular endothelial growth factor, VEGF)浓度的变化。方法40例经多导睡眠图(polysomnography, PSG)检查诊断为OSAS的患者,根据夜间缺氧程度分为2组(重度夜间缺氧组和非重度夜间缺氧组),每组各20例。清晨空腹采用检测血浆VEGF浓度。结果重度夜间缺氧组血浆VEGF浓度为(125.96±99.04)pg/ml,而非重度夜间缺氧组血浆VEGF浓度为(49.83±17.16)pg/ml,二者之间有显著差异。血浆VEGF浓度与夜间缺氧程度呈正相关(r=0.743,P<0.01)。结论重度夜间缺氧的OSAS患者血浆VEGF浓度明显升高,OSAS患者夜间缺氧的严重程度呈血浆VEGF浓度正相关。Objective: To investigate the relationship between the level of plasma vascular endothelial growth factor (VEGF) and the severity degree of obstructive sleep apnea syndrome (OSAS). Methods: Forty patients with OSAS were evaluated by polysomnography during sleep. The concentration of plasma VEGF was measured by ELISA in samples obtained from the antecubital vein at 7 a.m. Results: Patients with severe nighttime hypoxia had significantly higher plasma VEGF levels compared with mild to moderate nighttime hypoxia ones [(154.96±99.04) pg/ml versus (49.83±17.16) pg/ml]. The degree of nocturnal oxygen desaturation in OSAS was significantly correlated with plasma VEGF level (r =0.743,P <0.01). Conclusion: The plasma level of VEGF is elevated in OSAS patients with severe hypoxia and related to the severity degree of nocturnal oxygen desaturation.

关 键 词：睡眠呼吸暂停综合征 阻塞性 血管内皮生长因子 多导睡眠图 经皮血氧饱和度 

分 类 号：R766.43[医药卫生—耳鼻咽喉科]