复方林蛙油冲剂对辐射损伤大鼠白细胞及丙二醛的影响  

Effects of rana japonica oil compound granules on white blood cells and serum MDA in rats subjected to pre-and post-irradiation

作　　者：杨帆[1] 孙鹏飞[1] 孙明妮[1] 王芸芸[1] 岳超[1] 李春卉[1] 王程[1] 沈楠[1] 曲保忠[1] 

机构地区：[1]吉林医药学院,吉林吉林132013

出　　处：《吉林医药学院学报》2010年第2期82-84,共3页Journal of Jilin Medical University

基　　金：吉林医药学院大学生基金资助(No:吉医学科[2008]第14号)

摘　　要：目的探讨长白山复方林蛙油冲剂对X射线照射Wistar大鼠外周血白细胞(WBC)及丙二醛(MDA)的影响。方法复制X射线辐射大鼠模型,用复方林蛙油冲剂进行干预,观察各组大鼠WBC及MDA含量的变化。结果大鼠经X线照射后,外周血白细胞总数比正常空白对照组显著降低(P<0.05);照射前给予复方林蛙油冲剂,显示辐射大鼠血清WBC显著升高(P<0.05)。X线照射后7 d,各实验组大鼠血清MDA含量无显著差异(P>0.05)。结论复方林蛙油冲剂具有一定的抗X线辐射损伤作用。Objective To obersve the effects of rana japonica oil compound granules on white blood cells(WBC) and serum MDA in Wistar rats subjected to pre-and post-irradiation.Methods The models of wistar big mice under X radiation were copied and the intervened with the compound prescription powder made from rana japonica oil,the WBC number and MDA activity in the pre-and post-irradiation were observed.Results After the irradiation,WBC total obviously reduced compared to the normal blank control group(P<0.05);number of WBC significantly increased when rana japonica oil compound granules was given to rats before irradiation(P<0.05),there was no significant difference in the contents of MDA in all the rats after seven days′ irradiation(P>0.05).and treatment of rana japonica oil compound granules to rats pre-and post-irradiation decreased MDA activity.Conclusion Compound prescription powder mainly made from rana japonica oil had protective effects on big mice with irradiation damage induced by X-rays.

关 键 词：林蛙油 X射线照射 白细胞 丙二醛 

分 类 号：R392.12[医药卫生—免疫学]