X射线低剂量多次照射对大鼠血清氧化指标的影响  

Effect of low dose X-ray radiation on serum oxidative indexes in mice

作　　者：杨帆[1] 孙鹏飞[1] 黄鹤[2] 王芸芸[1] 刘贺[1] 曹志友[1] 曲宝忠[1] 

机构地区：[1]吉林医药学院,吉林吉林132013 [2]空军总医院,北京100142

出　　处：《吉林医药学院学报》2010年第5期265-267,共3页Journal of Jilin Medical University

基　　金：吉林医药学院大学生科研基金资助项目(NO:吉医学科字[2008]第14号)

摘　　要：目的探讨X射线低剂量多次照射对大鼠血清超氧化物歧化酶(T-SOD)活力、丙二醛(MDA)含量、红细胞计数(WBC)及抑制.OH能力的影响。方法建立大鼠X射线低剂量照射模型,检测各组大鼠血清中T-SOD活力、MDA含量、WBC及抑制.OH能力。结果两组实验大鼠血清T-SOD活力、MDA含量无统计学意义;空白对照组大鼠血清WBC含量明显高于X射线照射组(P<0.05);空白对照组大鼠血清抑制.OH能力显著高于X射线对照组(P<0.05)。结论总剂量(329±6)mGy/d的X射线照射对机体的抗氧化指标、.OH和造血系统有一定的影响。Objective To study the effect of low dose X-ray radiation on serum T-SOD,MDA,WBC,·OH in mice.Methods The models of Wistar big mice under low dose X-ray radiation were established and the T-SOD activity,MDA content,WBC and suppression,·OH ability of serum were examined.Results There was no significant difference in T-SOD activity and the content of MDA in all the rats;Content of WBC in the blank control group was obviously greater than that in the X-ray radiation group(P<0.05).The serum suppression ·OH ability in blank control group was obviously higher than that in the X-ray radiation group(P<0.05).Conclusion Low dose X-ray radiation(total dose(329±6)mGy/d)had certain influence on organism antioxidant indexes,·OH and hematopoietic system.

关 键 词：X射线 低剂量 氧化指标 

分 类 号：R392.3[医药卫生—免疫学]