住院患者肠杆菌科细菌感染的临床特征及耐药性分析  

Analysis of clinical features and antibiotics resistance of enterobacteriaceae spp in hospitalized patients

作　　者：方德洋[1] 陈爽[2] 姜晓明[2] 

机构地区：[1]吉化集团总医院检验科,吉林吉林132022 [2]吉林医药学院,吉林吉林132013

出　　处：《吉林医药学院学报》2010年第6期327-330,共4页Journal of Jilin Medical University

摘　　要：目的了解近3年吉化集团总医院肠杆菌科细菌感染的临床特征及耐药现状,为临床抗感染治疗提供科学依据。方法收集2007年7月至2010年6月各类临床标本,常规方法培养鉴定细菌,K-B纸片法进行药物敏感性试验。结果共分离出肠杆菌科细菌406株,检出率排前3位的依次是大肠埃希菌(169株)、肺炎克雷伯菌(117株)和阴沟肠杆菌(39株),标本主要分布于痰、创面分泌物和尿液中。超广谱β-内酰胺酶(ES-BLs)在大肠埃希菌、肺炎克雷伯菌、产酸克雷伯菌和奇异变形杆菌的检出率分别为50.89%、17.95%、42.86%和11.11%。未见亚胺培南和美罗培南耐药株,对所监测的其他抗菌药物均存在不同程度的耐药。结论 临床感染肠杆菌科细菌以大肠埃希菌和肺炎克雷伯菌为主,感染部位以下呼吸道最常见,最敏感的药物是亚胺培南和美罗培南,临床应根据药敏结果合理使用抗菌药物。Objective To investigate clinical features and drug resistance of enterobacteriaceae spp in Jilin area in recent 3 years to provide scientific basis for anti-infective treatment in clinic.Methods Clinical samples from June 2007 to July 2010 were collected,Bacteria were developed and identified by routine methods,antibiotics susceptibility was tested by K-B method.Results A total of 406 strains of enterobacteriaceae spp were isolated,the detection rates of bacteria in the first 3 was as follows in order:E coli(169),K.pneumoniae(117) and E.cloaca(39).The distribution of specimens came mainly from sputum,urine and wound secretions.The detection rates of extended spectrum beta-lactamases(ESBLs) producing E.coli,K.pneumoniae,K.oxytoca and P.mirabilis were 50.89%,17.95%,42.86% and 11.11%,respectively.All isolates were sensitive to imipenem and meropenem,but these bacteria had various resistances to other tested antibiotics.Conclusion Clinical infection was caused mainly by E.coli,K.pneumoniae and E.cloacae and occurred mainly in lower respiratory tract.Imipenem and meropenem remain highly active and antibiotics should be correctly used according to susceptibility.

关 键 词：肠杆菌科细菌 感染 耐药性 

分 类 号：R378.1[医药卫生—病原生物学]