2,5-二氯苯酚的制备研究  

A Study on the Preparation of 2,5-Dichlorophenol

作　　者：王玉灿[1] 马瑛[1] 孟明扬[1] 高嘉新[1] 刘东[1] 杨文东[1] 

机构地区：[1]沈阳化工研究院有限公司,沈阳110021

出　　处：《染料与染色》2012年第3期15-16,20,共3页Dyestuffs and Coloration

摘　　要：本文阐述了一种以毒性相对较小的1,2,4-三氯苯为原料,在溶剂中碱性水解制备2,5-二氯苯酚的合成方法。以甲醇作溶剂,在相转移催化剂作用下,1,2,4-三氯苯与氢氧化钠在195℃下进行碱性水解6个小时,粗产品2,5-二氯苯酚重结晶后的含量在97%以上,收率83%。本工艺流程简单、后处理方便,产品纯度较高。A synthesis method of 2,5-dichlorophenol was described,it was 2,5-dichlorophenol synthesized from a relatively low toxicity intermediate 1,2,4-trichlorobenzene in a solvent by alkaline hydrolyzation.In the presence of PTC,1,2,4-trichlorobenzene was hydrolyzed with NaOH in methanol at 195 ℃ for 6 hours.The content of recrystallized crude product 2,5-dichlorophenol was up to 97% with the yield 83%.The synthesis process was simple with convenient post-processing and a high purity of product.

关 键 词：相转移催化剂 催化 碱性水解 重结晶 

分 类 号：TQ243.2[化学工程—有机化工]