组合型人工肾治疗维持性血液透析伴皮肤瘙痒  

The Clinical Effects of Hemoperfusion Combined with Hemodialysis on Pruritus in the Maintenance Hemodialysis Patients

作　　者：李六生[1,2] 陈晓芳[1,2] 李书会[1,2] 陈飞[1,2] 

机构地区：[1]三峡大学人民医院 [2]宜昌市第一人民医院肾内科,湖北宜昌443000

出　　处：《湖北医药学院学报》2012年第1期59-61,共3页Journal of Hubei University of Medicine

摘　　要：目的:探讨组合型人工肾治疗维持性血液透析(MHD)伴皮肤瘙痒患者的疗效。方法:48例伴皮肤瘙痒的MHD患者随机分为观察组和对照组各24例,分别采用组合型人工肾治疗与常规血液透析治疗4周,观察皮肤瘙痒改善情况,测定治疗前后血甲状旁腺激素(PTH)水平。结果:观察组患者皮肤瘙痒缓解率(87.5%)显著优于对照组(8.33%)(P<0.01),瘙痒评分及血PTH较治疗前明显下降(P<0.01),且上述指标与对照组相比有统计学意义(P<0.01)。结论:组合型人工肾治疗能有效清除尿毒症毒素,改善MHD患者的皮肤瘙痒症状。Objective To investigate the therapeutic effect of hemoperfusion(HP) combined with hemodialysis(HD) on pruritus in the maintenance hemodialysis patients(MHD).Methods Forty-eight MHD with pruritus were randomly divided into two groups with 24 cases each,the Observation group was treated with HP/HD for 4 weeks while the control group was treated with HD.The changes of pruritus score and serum parathyroid hormone(PTH)in two groups were recorded before and after treatment.Results The total remission rate in the observation group was 87.5%,higher than the control group(8.33%)(P<0.01).The levels of pruritus score and PTH,declined significantly(P<0.01) compared with those before treatment in Observation group,and these changes were also remarkably different compared with those in control group(P<0.01).Conclusion The combined application of hemoperfusion and hemodialysis can effectively eliminate uremic and relief symptoms of pruritus.

关 键 词：血液透析 血液灌流 皮肤瘙痒 尿毒症 

分 类 号：R459.5[医药卫生—治疗学]