颈动脉粥样硬化斑块形成的相关因素  

Relevant Factors in the Formation of Plaque in Patients with Carotid Atherosclerosis

作　　者：龚丛芬 孙慧[2] 丁琼[1] 王静[2] 刘俊[1] 

机构地区：[1]武汉大学基础医学院,湖北武汉4300711 [2]湖北医药学院附属太和医院神经内科,湖北十堰442200

出　　处：《湖北医药学院学报》2012年第4期267-270,共4页Journal of Hubei University of Medicine

摘　　要：目的:研究颈动脉粥样硬化斑块形成的各相关危险因素与其动脉病变严重程度的关系。方法:选择2010年10月至2011年12月在本院行颈动脉彩色多普勒超声检查的患者180例,分为斑块组(n=86)和无斑块组(n=94),记录患者一般情况并检测静脉血中血脂相关指标值,采用logistic回归模型分析各因素与斑块形成的关系。结果:单因素分析结果显示,与无斑块组相比,斑块组的高血压发生率、糖尿病、饮酒史和血脂生化检测中总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A(ApoA)、脂蛋白[Lp(a)]、纤维蛋白原(FIB)均显著增高(P<0.05),而年龄、性别、吸烟史和LDL-C、载脂蛋白B(ApoB)则无统计学意义(P>0.05);多因素分析发现高血压、糖尿病、Lp(a)、TC、TG与颈动脉粥样硬化呈显著正相关。结论:多种危险因素共同作用导致颈动脉血管硬化斑块的发生,其中高血压、糖尿病、Lp(a)、TC、TG是导致颈动脉硬化斑块形成的相关危险因素,HDL-C则是保护因素。Objective To investigate the relationship between relevant factors in the formation of carotid atherosclerotic plaque and severity of arterial lesion in patients with carotid atherosclerosis.Methods From October 2010 to December 2011 in our hospital,180 patients which underwent carotid color Doppler ultrasound were selected and divided into plaque group(86 cases) and non-plaque group(94 cases).The clinical data of patients were recorded,and the indexes of venous blood lipid were determined.The relationship between blood lipid indexes and plaque formation was analyzed with logistic regression.Results The results of one-factor analysis of variance demonstrated that the relevant factors such as hypertension,diabetes,history of alcohol consumption,and TC,TG,HDL-C,ApoA,Lp(a),FIB of lipid biochemical test in plaque group were significantly higher than those in non-plaque group(P<0.05).Meanwhile,the age,gender,smoking history,LDL-C and ApoB had no significant difference between two groups(P>0.05).The results of multifactor analysis of variance demonstrated that hypertension,diabetes,Lp(a),TC,TG were positively correlated with the incidence of carotid atherosclerosis.Conclusion The formation of carotid atherosclerotic plaque is a multi-factor-involved process,and hypertension,diabetes,Lp(a),TC,TG are risk factors,but HDL-C is a protective factor.

关 键 词：颈动脉粥样硬化 心脑血管疾病 危险因素 斑块形成 

分 类 号：R445.1[医药卫生—影像医学与核医学]