三种心血管支架用金属材料的表面特性与生物相容性  

Surface Characteristics and Biocompatibility of Three Metals for Cardiovascular Stents

作　　者：吴锋[1] 孟改利[1] 董兵辉[2] 刘保国[2] 周益敏 付涛[2] 

机构地区：[1]西安交通大学医学院,西安710061 [2]西安交通大学生命科学与技术学院,西安710049

出　　处：《生物医学工程研究》2012年第2期91-94,共4页Journal Of Biomedical Engineering Research

基　　金：陕西省科技计划(2007K06-08);中央高校基本科研业务费专项资金资助项目(xjj2011096)

摘　　要：考察了316L不锈钢、NiTi合金和TLM钛合金的表面特性、血液相容性和内皮化能力,以筛选心血管支架材料。结果表明,316L不锈钢具有较好的血液相容性,内皮细胞生长良好,但耐蚀性差;NiTi合金的耐蚀性和血液相容性优良,内皮细胞生长状况良好。TLM合金由生物相容性元素组成,其耐蚀性好,但表面粗糙度较高,亲水性差,影响了材料的血液相容性和内皮化能力。作为心血管支架材料,三种材料中NiTi合金具有最好的生物相容性。Surface characteristics,hemocompatibility and endothelium of 316L stainless steel,NiTi alloy and TLM titanium alloy were investigated for the selection of cardiovascular stent material.316L stainless steel had good hemocompatibility and endothelium,but weak corrosion resistance.NiTi alloy exhibited overall good properties.TLM alloy,which is composed of biocompatible elements,had good corrosion resistance,but its high surface roughness and weak hydrophilicity brought down its hemocompatibility and endothelium capacity.For cardiovascular stent application,NiTi alloy has the best biocompatibility among the three materials.

关 键 词：不锈钢 NITI合金 TLM合金 耐蚀性 血液相容性 内皮化 

分 类 号：R318.08[医药卫生—生物医学工程]