乌苏里藜芦生物碱单体计米丁对家兔血液流变学的影响  

Study on Hemorrheology Effect of Germidine,an Alkaloid Isolated from Veratrum Nigrum L.Var Ussuriense Nakai

作　　者：吕莉[1] 齐万红[2] 潘平[1] 周琴[1] 赵伟杰[3] 王世盛[3] 韩国柱[1] 

机构地区：[1]大连医科大学药理教研室,大连116044 [2]大连市第三人民医院,大连116000 [3]大连理工大学精细化工国家重点实验室,大连116012

出　　处：《血栓与止血学》2011年第6期254-257,共4页Chinese Journal of Thrombosis and Hemostasis

基　　金：国家自然科学基金课题(NSFC20372014);辽宁省教育厅课题(2010048)

摘　　要：目的研究乌苏里藜芦生物碱单体计米丁(germidine)对血液流变学的影响。方法测定给予计米丁后20 min、60 min、120 min家兔全血和血浆黏度,5 min血小板最大聚集率、复钙时间(RT)和凝血酶时间(TT)。结果与给药前相比,家兔静注计米丁(1.25～10.00μg/kg)后呈剂量依赖性地降低全血和血浆比黏度,呈剂量和时间依赖性地抑制5 min血小板最大聚集率,同时呈剂量依赖性地抑制RT和TT。结论计米丁具有强大降低血黏度、抑制血小板聚集和抗凝活性,是乌苏里藜芦生物碱改善血液流变学的主要成分之一。Objective To study the hemorrheology effect of germidine in rabbits. Methods Blood viscosity,plasma viscosity,ex vivo platelet aggregation,RT and TT were determined before and after iv administered germidine 20 min,60min and 180min at the dosage of 1.25~10.00 μg/kg in rabbits. Results In comparison with predose,4 different doses(1.25~10.00 μg/kg) of germidine showed significantly and dose-dependently inhibited blood viscosity,plasma viscosity,and ex vivo platelet aggregation,prolonged RT and TT. Conclusion Germidine has powerful hemorrheology effect,and plays an important role in the hemorrheology effect of var ussuriense nakai aldaloid.

关 键 词：乌苏里藜芦生物碱 计米丁 全血黏度 血浆黏度 血小板聚集 

分 类 号：R28[医药卫生—中药学]