重组牛碱性成纤维细胞生长因子眼凝胶在眼部皮肤外伤的应用与护理  

Applicaton of recombinant bovine basic fibroblast growth factor eye gel on sutured periorbital skin lacerations and nursing practice

作　　者：杨丽萍[1] 尹婕[1] 程莹莹[1] 

机构地区：[1]南京军区南京总医院眼科,南京210002

出　　处：《医学研究生学报》2011年第7期736-737,共2页Journal of Medical Postgraduates

基　　金：国家自然科学基金(30670600)

摘　　要：目的重组牛碱性成纤维细胞生长因子(recombinant bovine basic fibroblast growth factor,rb-BFGF)眼凝胶在眼科临床上主要用于病毒性角膜炎、角膜溃疡。外科又将其用于压疮的皮肤换药中,收效良好。文中首次将rb-BFGF眼凝胶应用于眼部皮肤外伤,以观察对创面愈合的影响。方法将86例门诊眼部皮肤外伤的患者分为治疗组46例,对照组40例,分别应用rb-BFGF眼凝胶和常规换药,观察创面愈合情况。结果创面愈合时间,治疗组为(4.26±0.61)d,对照组为(5.15±0.48)d,P<0.001。治疗组创面无感染,且疤痕明显小于对照组,未见眼部及局部伤口不良反应。结论眼部皮肤外伤缝合后,用rb-BFGF眼凝胶涂抹创面可加速创面愈合,减轻疤痕形成,应用安全。Objective The recombinant bovine basic fibroblast growth factor ege gel has been the drug treatment recommended for patients with viralkeratitis and keratohelcosis.And it is also used for changing dressing in surgery which has good effect.The aim of this study is to investigate the influence of recombinant bovine basic fibroblast growth factor eye gel on sutured periorbital skin lacerations Methods A total of eighty-six cases with skin lacerations in periorbital area were selected.All cases were randomly divided into treatment group(recombinant bovine basic fibroblast growth factor eye gel combined with wound dressing) and control group(only wound dressing).Patients were followed up every day for 1 week.Results Wound healing time of the treatment group(4.26±0.61) days was faster than that of the control group(5.15±0.48) days(P<0.001).No infection occurred in all cases.The scar in the treatment group was less obvious than that in the control.There was no adverse reaction in the treatment group.Conclusion Application of recombinant bovine basic fibroblast growth factor eye gel on sutured periorbital skin lacerations promotes the wound healing,lessens the scars and is proven safe.

关 键 词：眼部外伤 创面愈合 重组牛碱性成纤维细胞成长因子眼凝胶 护理 

分 类 号：R47[医药卫生—护理学]