海洋生物抗肿瘤多肽海兔毒素10及其衍生物的研究进展  

Research advances on marine antitumor peptides dolastatin 10

作　　者：曹王丽[1,2] 宋佳希[1] 李芳秋[1] 

机构地区：[1]南京军区南京总医院解放军检验医学研究所,南京210002 [2]南京师范大学生命科学院,南京210097

出　　处：《医学研究生学报》2011年第11期1208-1211,共4页Journal of Medical Postgraduates

基　　金：国家自然科学基金(30670599)

摘　　要：海兔毒素10(dolastatin 10,D10)是从海洋无壳软体动物截尾海兔(Dolabella auricularia)中分离提取的由4个氨基酸组成的线性缩肽类天然毒性蛋白。dolastatin 10及其衍生物可以抑制细胞有丝分裂,具有很强的抗肿瘤活性,已进入临床研究阶段。文中综述对dolastatin 10的发现、结构特点与作用机制,其衍生物及衍生物与相应单克隆抗体偶联物的临床疗效。] Dolastatin 10,a cytostatic depsipeptide containing four unique amino acid subunits,was isolated from the marine shell-less mollusk Dolabella auricularia.Dolastatin 10 and its derivatives,which demonstrated antimitotic,antiproliferative and growth inhibitary activities in tumor cells through inhibition of tubulin polymerization,have been used in clinical studies.In this review,we described the discovery,cytotoxicity,structure features,action mechanism and clinical studies of dolastatin 10.The therapeutic efficacy of dolastatin 10 derivatives and their monoclonal antibody conjugates were particularly discussed.

关 键 词：海兔毒素10 抗有丝分裂剂 dolastatin 10衍生物 

分 类 号：R11[医药卫生—公共卫生与预防医学]