胰岛素及其类似物与肿瘤相关性研究进展  

Relationship of insulin and insulin analogue with cancer: An update

作　　者：周佳雁[1] 沈捷[1] 马向华[1] 

机构地区：[1]南京医科大学第一附属医院内分泌科,南京医学硕士研究生210029

出　　处：《医学研究生学报》2011年第12期1336-1339,共4页Journal of Medical Postgraduates

摘　　要：大量研究发现,在多种癌症患者中均伴有血浆胰岛素水平的升高,而体内高水平的胰岛素尤其是有胰岛素抵抗的患者,患各种肿瘤的危险性明显增高。高水平的血浆胰岛素可能通过胰岛素信号经典途径放大胰岛素的促生长作用,同时,也可通过改变胰岛素样生长因子(insulin-like growth factor,IGF)信号途径作用,产生协同促细胞增殖及抗细胞凋亡作用,从而诱导肿瘤的形成。由于胰岛素现已成为糖尿病患者降血糖的主要手段之一,越来越多的研究者开始关注接受胰岛素治疗的糖尿病者其肿瘤的发生风险是否会增高。结果显示,无论接受人胰岛素还是胰岛素类似物治疗,肿瘤形成的风险均增高,而同人胰岛素相比,使用胰岛素类似物是否会更加促肿瘤的发生尚存争议。Hyperinsulinemia has a close relationship with many cancers,and there is a higher risk of cancer in patients with hyperinsulinemia and particularly in those with insulin resistance.Hyperinsulinemia can amplify the growth-promoting effect of insulin via classical signaling,produce synergetic cell proliferation-promoting and anti-cell-apoptosis effects by changing the insulin-like growth factor(IGF) signaling pathway,and consequently induce tumor formation.Given the fact that insulin has became one of the most effective glucose-lowering therapies in diabetic patients,researchers are paying more and more attention to the issue whether diabetic patients who receive any insulin therapy are exposed to a greater cancer risk than those who don′t.Findings show that either human insulin or insulin analogue is associated with an increased risk of cancer,though controversy does exist whether insulin analogue induces a higher cancer incidence than human insulin.

关 键 词：胰岛素 胰岛素受体 胰岛素样生长因子-1受体 胰岛素类似物 肿瘤 

分 类 号：R58[医药卫生—内分泌]