PI3K信号通路对T细胞发育、活化、增殖、分化及支气管哮喘的作用  

Role of PI3K signal in development,activation,differentiation of T cell and bronchial asthma

作　　者：聂颖[1] 李昌崇[1] 

机构地区：[1]温州医学院附属育英儿童医院呼吸科,325027

出　　处：《中华哮喘杂志（电子版）》2011年第5期348-352,共5页Chinese Journal of Asthma(Electronic Version)

基　　金：浙江省自然基金资助项目(Y2090327);浙江省大学生科技创新活动计划(新苗人才计划)资助项目(2010R413044)

摘　　要：T细胞是参与支气管哮喘发病的重要效应细胞,而磷脂酰肌醇-3-激酶(PI3K)是T细胞的重要信号转导分子。PI3K信号通过影响双阴性细胞的β-选择而影响T细胞的成熟,还通过激活PKB、Rac等信号途径而参与T细胞的活化、分化。同时,PI3K通过参与Th1/Th2失衡的调节,嗜酸粒细胞、肥大细胞的黏附、脱颗粒等而参与支气管哮喘气道炎症反应。T lymphocyte is the core cell in the bronchial asthma.The phosphoinositide3-kinase(PI3K) pathway is the important signal transduction pathway in the T lymphocyte.PI3K signaling plays a role in the development of T cells through affecting the double-negative cells of the β-selection,and T cell activation and differentiation through activation of PKB,Rac and other signaling pathway.At the same time,PI3K signal also involved in the airway inflammation of asthma including the regulation of Th1/Th2 imbalance,adhesion,degranulation of eosinophils and mast cells.

关 键 词：PI3K信号 T细胞 发育 分化 哮喘 

分 类 号：R56[医药卫生—呼吸系统]