生石膏对大鼠胃酸分泌及胃粘膜屏障的影响  

Effects of Gypsum on Gastric Acid Secretion and Gastric Mucosal Barrier Function in Rats

作　　者：秦明[1] 滕光寿[1] 王景杰[1] 杨琦[1] 赵保民[1] 王旭霞[1] 黄裕新[1] 

机构地区：[1]第四军医大学唐都医院,陕西西安710038

出　　处：《中医药学报》2011年第5期16-18,共3页Acta Chinese Medicine and Pharmacology

基　　金：国家自然科学基金资助项目(编号:30801487);陕西省中医药管理局中医药科研课题基金资助项目(36)

摘　　要：目的:探讨寒性药物生石膏对大鼠胃粘膜屏障损伤的机制。方法:30只雄性SD大鼠随机分为空白对照组、生石膏灌胃组和生理盐水灌胃组。实验结束后利用激光多普勒血流仪测定胃黏膜血流量,测定动物的胃结合粘液、空腹胃液量和胃液酸度,并取各组动物的胃粘膜组织测定表皮生长因子(epi-dermal growth factor,EGF)和一氧化氮(nitric oxide,NO)含量。结果:生石膏组与对照组比较,大鼠的胃黏膜血流量及胃结合粘液量明显减少,而空腹胃液量和胃液酸度均明显增加,且胃组织内NO和EGF含量明显减少;而生理盐水组与对照组之间差异无统计学意义。结论:生石膏伤胃与其破坏胃粘膜屏障作用有关。Objective:To investigate the mechanisms of cold-property Gypsum on gastric mucosal lesion in rats.Methods:Thirty male SD rats were randomized into three groups: control group,Gypsum gastric gavage group and NS gastric gavage group(NS).The animal's Gastric mucosal blood flow(GMBF) was measured directly by laser doppler flowmeter(LDF),the gastric wall mucus(GWM),fasting gastric juice volume and acidity were measured.The gastric mucosa levels of EGF and NO were measured.Results:Compared with the control group,the mean value of GMBF and GWM were decreased;The gastric juice volume and acidity were increased;The level of EGF and NO were great decreased in the Gypsum group.There was slightly difference between the control and the NS groups.Conclusion:The Gypsum can injure the stomach of rats,and this characteristic may be connected with its damage of gastric mucosal barrier function.

关 键 词：生石膏 胃粘膜 胃酸 EGF NO 

分 类 号：R28[医药卫生—中药学]