风药对肝郁脾虚型UC大鼠结肠黏膜病理损伤的影响  

The Effect of Fengyao on Experimental Ulcerative Colitis in Rats with Spleen Deifciency and Liver Depression

作　　者：马丽[1] 郭军雄[1] 王小莲[1] 

机构地区：[1]张掖医学高等专科学校,甘肃张掖734000

出　　处：《中医药学报》2011年第5期43-45,共3页Acta Chinese Medicine and Pharmacology

基　　金：甘肃省教育厅基金资助项目(NO.1030-02)

摘　　要：目的:本研究主要观察中药风药对肝郁脾虚型UC大鼠肠黏膜病理损伤的影响。方法:50只Wistar大鼠随机分为空白对照组、模型组、痛泻要方加风药组、痛泻要方组、痛泻要方祛防风组,每组10只,用结肠黏膜组织致敏法加乙酸局部刺激法建立大鼠复合溃疡性结肠炎模型后,用药组分别给予痛泻要方加风药、痛泻要方、痛泻要方祛防风药灌胃,模型对照组和正常对照组给予生理盐水,均灌胃4周后处死大鼠,分离其结肠组织,计算肠重指数,评价黏膜充血、组织损伤。结果:痛泻要方加风药、痛泻要方组在改善大鼠肠重指数、结肠黏膜充血、组织损伤方面明显优于痛泻要方祛防风组。结论:风药通过减轻UC模型大鼠结肠组织炎性反应,减缓黏膜充血水肿来促进实验性UC大鼠溃疡愈合的作用。Objective:To study the effect of Fengyao on experimental ulcerative colitis(UC) in rats with spleen deifciency and liver depression.Methods: Fifty healthy Wistar rats were randomly divided into 5 groups:normal control group,model group,TXYF+Fengyao,TXYF and TXYF-Fangfeng group(n=10 rats per group),The ulcerative colitis in the model group and positive group was developed by immunological sensitization with colon mucosal proteins and local irritation with five percent acetic acid.The rats of the model and positive groups were fed with TXYF+Fengyao,TXYF and TXYF-Fangfeng,and rats of the control group were fed with normal saline.Four weeks later,all rats were killed and colon mucosal samples were collected.Colonic weight index was calculated and colonic mucosal hyperemia and damage index were reviewed.Results: The effects of TXYF+Fengyao,TXYF were superior in the improvement of colonic weight index,colonic mucosal hyperemia and damage index to TXYF-Fangfeng.Conclusion:Fengyao has a function of restraining inflammatory reaction and colonic mucosal hyperemia on experimental ulcerative colitis in rats.

关 键 词：风药 溃疡性结肠炎 肠重指数 充血积分 组织损伤评分 

分 类 号：R25[医药卫生—中医内科学]