基于D-优化设计的那拉曲坦给药方案的建模与仿真  

Modeling and Simulation for Dosing Regimen of Naratriptan based on D-optimal Design

作　　者：孙鹤[1] 施心陵[2] 赵磊[2] 刘亚杰[3] 

机构地区：[1]云南大学信息学院电子工程系,昆明50091 [2]不详 [3]云南省肿瘤医院,昆明650118

出　　处：《生物医学工程研究》2012年第4期238-240,共3页Journal Of Biomedical Engineering Research

基　　金：国家自然科学基金资助项目(60861001)

摘　　要：以那拉曲坦为例,建立药效学模型,应用D-优化设计计算相应Fisher信息矩阵,将不同给药方案下的实验结果进行量化,直观给出合理的给药方案。设计5种不同给药方案组,计算对应的Fisher信息矩阵行列式并进行组间对照,最后得出合理的给药方案。通过试验仿真结果可以对临床给药给出适当的指导。To establish the pharmacodynamic model of Naratriptan and calculate the Fisher information matrix,with the application of the D-optimal design and quantify the experimental results under different dosing regimens,intuitive given reasonable dosing regimen.Five different dosing regimen groups were designed to calculate the corresponding Fisher information matrix determinant and compare between the groups,and finally came to a reasonable dosage regimen.From the results of the model,which can gave a reference to the dose of naratriptan on the clinical trial.

关 键 词：计算机模拟 那拉曲坦 D-优化设计 Fisher信息矩阵 药效学 

分 类 号：R96[医药卫生—药理学]