牙周病与喉鳞状细胞癌相关性的Meta分析  

Meta-analysis of Association between Periodontal Disease and Laryngeal Squamous Cell Carcinomas

作　　者：陈永吉[1] 黄伟[1] 邬兰[2] 吴凡[2] 曾宪涛[1] 

机构地区：[1]湖北医药学院附属太和医院口腔科,湖北十堰442000 [2]湖北医药学院口腔医学院,湖北十堰442000

出　　处：《湖北医药学院学报》2013年第2期121-124,共4页Journal of Hubei University of Medicine

基　　金：湖北省科技厅2012年度面上项目(2012FFB03902);湖北省教育厅科学技术研究计划2012年度重点项目(D20122405);湖北省教育科学"十二五"规划2012年度重点课题(2012A050)

摘　　要：目的:采用Meta分析的方法探讨牙周病与喉鳞状细胞癌的相关性。方法:检索PubMed数据库中自建库至2012年10月30日之间公开发表的文献,对符合纳入标准的研究采用RevMan 5.1软件进行Meta分析。结果:最终纳入4个病例-对照研究共6 089例研究对象。Meta分析结果显示暴露于牙周病的人群罹患喉鳞状细胞癌的风险增加了1.79倍[OR=1.79,95%CI=(1.34～2.38)],敏感性分析显示结果稳健性好。结论:当前证据表明牙周病很可能是喉鳞状细胞癌的一个独立的、有意义的危险因素。Objective To evaluate the association between periodontal disease and laryngeal squamous cell carcinomas(LSCC) by performing a meta-analysis.Methods The PubMed database was searched for relevant studies up to October 30,2012.The meta-analysis of included studies was conducted using the RevMan 5.1 software.Results Finally yield 4 case-control studies involving 6 089 individuals.The result of meta-analysis indicated that exposed to periodontal diseases could obviously increase of risk for LSCC 1.79 times,sensitivity analysis showed the result was robust.Conclusion Based on currently evidence,periodontal diseases is probably an independent and significant risk factor for LSCC.

关 键 词：牙周病 喉鳞状细胞癌 危险因素 META分析 

分 类 号：R781.4[医药卫生—口腔医学] R739.65[医药卫生—临床医学]