帕瑞昔布钠超前镇痛用于妇科腹腔镜手术  

Effects of Parecoxib on Preemptive Analgesia for Gynaecological Laparoscopic Surgery

作　　者：钟和英[1] 郑敏[1] 田刚[1] 冉然[1] 付俊[1] 

机构地区：[1]湖北医药学院附属人民医院麻醉科,湖北十堰442000

出　　处：《湖北医药学院学报》2013年第2期150-153,共4页Journal of Hubei University of Medicine

基　　金：2012年十堰市科学技术研究与开发项目计划(078S)

摘　　要：目的:评价帕瑞昔布钠超前镇痛用于妇科腹腔镜手术的效果和安全性。方法:选择择期全麻下行妇科腹腔镜手术患者60例,随机分为3组,每组20例。A组麻醉前10 min静脉注射帕瑞昔布钠40 mg,B组手术结束前10min静脉注射帕瑞昔布钠40 mg,C组麻醉前10 min静脉注射0.9%氯化钠溶液5 mL。观察T0(麻醉诱导前)、T1(气管插管时)、T2(手术开始后5 min)、T3(气管拔管时)及T4(手术结束后10 min)患者的MBP、HR、SpO2及PETCO2;用VAS评分评价患者术后1、2、4、8、12 h疼痛程度;记录术后Ramsay镇静评分及患者术后不良反应。结果:3组患者麻醉诱导前MBP、HR、SpO2及PETCO2差异均无统计学意义(P>0.05);T1、T2、T3各时点3组患者MBP、HR均不同程度升高,其中B、C组在T1、T2的MBP、HR均较A组升高明显(P<0.05);A、B组术后1、2、4、8 h VAS评分明显低于C组(P<0.05),A、B组术后1、2、4 h Ramsay镇静评分明显高于C组。3组术后不良反应发生率差异均无统计学意义。结论:帕瑞昔布钠术前预先给药用于妇科腹腔镜手术,可减轻术中心血管反应,缓解患者术中、术后疼痛反应,且术后不良反应发生率低。Objective To evaluate the preemptive analgesic effects and safety of parecoxib sodium for gynaecological laparoscopic surgery.Methods Sixty patients ASA Ⅰ~Ⅱ undergoing gynaecological laparoscopic surgery under general anesthesia were randomly divided into three groups(n=20).Parecoxib sodium were intravenously injected with 40 mg at 10 minutes before anesthesia and 10 minutes before the operation over in group A and group B,respectively.0.9% sodium chloride solution were intravenously injected with 5 mL at 10 minutes before anesthesia.MBP,HR,SpO2 and PETCO2 were recorded at the following time points,T0(before anesthesia),T1(trachea intubation),T2(5 minutes in the operation),T3(trachea extubation),T4(10 minutes after operation).The analgesic effect was evaluated by Visual Analogue Score(VAS) at 1,2,4,8 and 12 hours after operation.Ramsay sedation scale and adverse reactions were recorded.Results All the indexes before anesthesia had no significant difference during three groups(P<0.05).MBP,HR were all increased in three groups at T1,T2,T3,and MBP,HR in group B and group C were obviously increased than those of group A at T1 and T2(all P<0.05).The VAS of group A and group B were obviously lower than those of group C at all time points(all P<0.05).Ramsay sedation scale of group A and group B were obviously higher than those of group C at 1,2,4 hours after operation.There was no significant difference in adverse reaction of all groups.Conclusion Preemptive analgesia with parecoxib sodium is effective and safe in patients undergoing gynaecological laparoscopic surgery with less adverse reactions.

关 键 词：帕瑞昔布钠 超前镇痛 腹腔镜 

分 类 号：R614[医药卫生—麻醉学]