微重力环境影响免疫系统功能的研究进展  

Research progress of microgravity effects on immune system

作　　者：李琦[1] 梅其柄[1] 车速 杨慧[1] 黄庆生[1] 

机构地区：[1]西北工业大学生命学院空间生物实验模拟技术国防重点学科实验室,西安710072

出　　处：《中华航空航天医学杂志》2012年第4期300-305,共6页Chinese Journal of Aerospace Medicine

摘　　要：目的 通过文献综合分析航天飞行和地面模拟微重力环境对多种免疫细胞活性与功能的影响. 资料来源与选择 选择国内外该领域的相关研究论文和专著. 资料引用 国内外公开发表的文献50篇. 资料综合 来自长期航天飞行实践和地面模拟研究的结果均发现微重力环境影响多种免疫细胞活性与功能的现象,包括免疫细胞数量和亚群的改变,T细胞增殖活性的降低,多种细胞因子分泌水平的变化等. 结论 微重力环境可能是通过改变细胞表面受体及细胞功能基因的表达,影响细胞内信号通路的传递和细胞表观遗传事件等对免疫细胞产生负面影响.未来的研究应当进一步明确免疫细胞感受重力的分子机制,寻找能够逆转微重力环境下免疫细胞功能受到抑制的方法,为开展长期太空科学研究和空间生活提供保障.Objective To summarize the effects of space flight and ground simulated microgravity environment on immune cell's activity and functions.Literature resource and selection Domestic and international publications in this field were carefully retrieved.Literature quotation Fifty published research papers and reviews were cited.Literature synthesis Many studies have demonstrated that microgravity of space flight and simulated microgravity can affect the activity and functions of many kinds of immune cells,including altering the number and subset ratio of immune cells,reducing the mitogen-stimulated proliferation activity of T cells and affecting the secretion of cytokines,etc..Conclusions Microgravity can certainly cause negative effects on immune cells.Some fundamental cellular processes,such as expression of cell surface receptors,regulation of functional genes,transmission of signal pathways and epigenetic events may contribute to the effects of microgravity on immune cells.For further understanding of the effects of microgravity on immune cells,future studies should focus on the molecular mechanism among those related receptors,transduction signals and regulation genes.Countermeasures for preventing,such as the process of restoring immune cell's function from the restrain of microgravity effects,are expected.It will provide support for developing long-term space scientific research and space life.

关 键 词：失重 宇宙飞行 免疫 细胞 文献综述 

分 类 号：R852.22[医药卫生—航空、航天与航海医学]