脱落酸抑制剂氟啶酮对小鼠弓形虫病的影响  

Effect on the inhibitor for abscisic acid fluridone on infection of Toxoplasma gondii in mice

作　　者：孔璟[1] 叶彬[1,2] 武卫华[1,2] 

机构地区：[1]重庆医科大学病原生物学教研室,重庆400016 [2]重庆医科大学分子与肿瘤研究中心,重庆400016

出　　处：《中国人兽共患病学报》2012年第9期908-912,共5页Chinese Journal of Zoonoses

摘　　要：目的观察脱落酸抑制剂氟啶酮对小鼠弓形虫病的影响。方法给感染弓形虫RH株的小鼠腹腔注射氟啶酮,观察小鼠生存延长率、体重变化;光镜及电镜观察腹腔中弓形虫形态;脏器组织印片评估体内弓形虫扩散情况。结果与对照组相比,氟啶酮治疗的小鼠弓形虫病症状出现晚且程度较轻,生存时间延长(P<0.05),生存延长率为45%,体重减少率为6.13%,而对照组体重减少率为7.23%;对照组小鼠腹腔中以游离速殖子为主,实验组则以细胞内虫体为主;实验组小鼠脏器受虫体累及的时间稍晚,感染程度也比对照组轻。结论氟啶酮能对小鼠弓形虫病起抑制作用。To investigate the effect of fluridone,an inhibitor of abscisic acid,on mice infected with Toxoplasma gondii(T.gondii) RH strain,the mice infected with T.gondii were treated with fluridone by intraperitoneal injection in order to observe the survival time and the weight reduction rate of them.The modality of T.gondii in the intraperitoneal cavity of mice was observed by microscope and electron microscope,and the irradiation of T.gondii was evaluated by tissue printing.The symptom of toxoplasmosis in the group treated with fluridone appeared later and milder than those in the control group.The survival duration was longer(P<0.05) and the extension rate was 45%.The weight inhibitory rate of the treated mice was 6.13%,whereas that was 7.23% in the control mice.T.gondii in the control group were tachyzoites mainly,but intracellular parasite in mice was treated with fluridone.Destroy in organs happened later in the mice infected with T.gondii and the degree of infection was milder than in the control.These results suggested that fluridone could inhibit toxoplasmosis in mice,which were related to the function of blocking T.gondii egress and inducing development on vacuoles of intracellular by inhibiting abscisic acid.

关 键 词：刚地弓形虫 脱落酸 氟啶酮 

分 类 号：R535[医药卫生—内科学]