黄杉素分子印迹聚合物的合成与性能研究  

Synthesis and Characterization of Taxifolin Molecular Imprinted Polymer

作　　者：贺敏强[1] 何娟[1] 金兔红[1] 温成志[1] 程晓农[2] 

机构地区：[1]江苏大学化学化工学院,江苏镇江212013 [2]江苏大学材料科学与工程学院,江苏镇江212013

出　　处：《化学世界》2012年第7期407-411,共5页Chemical World

摘　　要：采用本体聚合法以黄杉素(Taxifolin,TAX)为模板分子,2-乙烯基吡啶(2-Vpy)为功能单体,乙二醇二甲基丙烯酸酯(EDMA)为交联剂,制备了黄杉素分子印迹聚合物(TAX-MIP)。通过紫外光谱考察了TAX与2-Vpy的非共价作用,并采用静态和动态结合实验评价了TAX-MIP对底物分子的结合特性。结果表明,TAX与2-Vpy通过静电作用形成主客体配合物,其结合常数和化学配位比分别为K=6.06×10 10(mol/L)-4和n=4;TAX-MIP对TAX存在不同亲和力的两类结合位点,并对TAX显示出很高的选择吸附特性和良好的分子识别性能;TAX-MIP对TAX的吸附符合准二级反应动力学方程。Taxifolin molecular imprinted polymer(TAX-MIP) was synthesized by molecular imprinting technique using taxifolin as template,2-vinylpyridine as a functional monomer and EDMA as a cross-linker.The non-covalent interactions between taxifolin and 2-vinylpyridine were observed by UV spectrophotometry.Taxifolin imprinted polymer's binding affinity to taxifolin was evaluated by both static and dynamic binding experiment.The results showed that a stable host-guest complex was formad prior to polymerization between taxifolin and 2-vinylpyridine with the dissociation constant and chemical combination ratio of 6.06×1010(mol/L)-4 and 1∶4,respectively.There were two classes of recognition sites in TAX-MIP,which had different affinity to taxifolin.Furthermore,TAX-MIP displayed excellent molecular recognition ability.Pseudo-second order equation was fitted for absorption of TAX on TAX-MIP.

关 键 词：黄杉素 分子印迹 吸附 选择性 

分 类 号：O639[理学—高分子化学] R284.2[理学—化学]