混合氨基酸钙剂的制备及生物学效应评价  

Preparation and Evaluation of Biological Effects of Mixed Amino Acid of Calcium

作　　者：张荣泉[1] 吕方[1] 杨萍[1] 

机构地区：[1]天津市医药科学研究所,天津300020

出　　处：《食品研究与开发》2012年第6期174-177,共4页Food Research and Development

摘　　要：通过发酵制备混合氨基酸钙剂,并对其生物学效应进行评价。德氏乳杆菌经发酵、灭活分离清液,得到混合氨基酸钙剂,检测其钙元素、游离氨基酸、维生素成分及卫生学指标;进行口服钙耐量、骨密度和骨组织病理影响、抗疲劳等动物实验,并做慢性毒性实验观察。混合氨基酸钙剂钙含量4.15 mg/mL,含18种游离氨基酸,动物实验显示实验组各项指标均高于对照组,慢性毒性实验未见异常。由德氏乳杆菌发酵制备的混合氨基酸钙剂含有多种氨基酸成分,有助于钙的溶解和肠吸收,具有良好的补钙效果。To prepare mixed amino acid calcium by fermentation of Lactobacillus dellbruckii and evaluate its biological activity.The mixed amino acid calcium was produced in the following ways: fermentation by of Lactobacillus delbruckii,inactivation and centrifugation.The detection experiments included: concentration of calcium,type of free amino acids,vitamin,and hygienic tests.The biological effects experiments included: calcium absorption,density of bone and anti-fatigue test.The toxicity experiment also undertook.The mixed amino acid calcium concentration was 4.15 mg/mL and had 18 kinds amino acid.Pharmacological experiments showed that all the indexes of experimental groups were better than control groups.And the chronic toxicity test showed that the mixed amino acid calcium was secure.The mixed amino acid calcium prepared by fermentation of Lactobacillus delbruckii can promote the dissolution and absorption of calcium and had favorable effect of calcium supplement

关 键 词：德氏乳杆菌 氨基酸钙 钙吸收 骨密度 抗疲劳 毒理 

分 类 号：R943[医药卫生—药剂学]