血清中β-HCG水平在早期异位妊娠中的诊断价值  

Diagnosis Value of Serumβ-HCG in Early Ectopic Pregnancy

作　　者：马锦霞 刘存芬 

机构地区：[1]红河州第一人民医院妇产科,云南红河661199

出　　处：《昆明医科大学学报》2012年第4期93-95,105,共4页Journal of Kunming Medical University

基　　金：云南省应用基础研究面上基金资助项目(2008CD012)

摘　　要：目的探讨血清人绒毛膜促性腺激素(β-HCG)在诊断早期异位妊娠中的临床价值.方法 2007年1月至2010年1月经确诊的71例早期异位妊娠的患者(病例组)和同期宫内早孕患者82例(对照组)作为研究对象.检测异位妊娠和宫内早孕患者外周血β-HCG含量,比较2组受试者β-HCG的差别,根据贝叶斯定理计算β-HCG在诊断异位妊娠中的价值,同时GraphPad Prism 5绘制受试者工作曲线(ROC)对诊断试验进行评价.结果实验组血清β-HCG水平为(931.6±412.6)U/L,对照组为(4 542.5±871.5)U/L,差别有统计学意义(P<0.05);以1 303 U/L为诊断异位妊娠的临界值,诊断试验的敏感为95.12%(95%CI87.9%～98.6%),特异性为78.9%(95%CI67.6%～87.7%),ROC曲线下面积(AUC)为0.91.结论血清β-HCG检测是临床上诊断异位妊娠较好的参考指标.Objective To evaluate the diagnostic value of the peripheral bloodβ-HCG in ectopic pregnancy.Methods 71 women with ectopic pregnancy and 82 intrauterine gestation women in our hospital from January 2007 to January 2011 were included.Peripheral blood β-HCG levels of 153 pregnancy women were tested.The peripheral blood-HCG levels of the two groups were compared.And ROC curve was used to analyse the diagnosis effect ofβ-HCG.Results The mean peripheral bloodβ-HCG levels of the ectopic pregnancy and intrauterine gestation were(931.6±412.6)U/L and(4 542.5±871.5)U/L,respectively.Singificant differences was detected between the two groups(P<0.05).The cutt-off value of 1751 U/L,sensitivity and specificity of progesterone as a serologic marker were 95.12%(95%CI87.9%～98.6%)and 78.9%(95%CI67.6%～87.7%) respectively.The under-curve area(AUC)of progesterone was 0.91.Conclusion Serum-HCG could be used as a good reference indicator for the diagnosis of ectopic pregnancy.

关 键 词：人绒毛膜促性腺激素 异位妊娠 诊断 

分 类 号：R446.1[医药卫生—诊断学]