nCPAP对T2DM合并重度OSAHS患者血浆中U-Ⅱ的临床疗效分析  

Changes of urotensin-II in plasma in patients with type 2 diabetes mellitus and severe OSAS complicated by hypertension before and after treatment by nCPAP

作　　者：杜婧[1] 陈更业[1] 李红梅[1] 李芳[1] 

机构地区：[1]宁夏自治区人民医院内分泌科,宁夏银川750021

出　　处：《宁夏医学杂志》2012年第8期709-710,共2页Ningxia Medical Journal

基　　金：宁夏自然科学基金资助项目(NZ08141)

摘　　要：目的探讨持续正压通气(nCPAP)对2型糖尿病(T2DM)合并重度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血浆尾加压素(U-II)的影响及其病理生理学的临床意义。方法采用整夜多导睡眠检测(PSG)并手动(nCPAP)压力滴定治疗T2DM合并重度OSAHS患者30例;放射免疫法测定治疗前后患者血浆中U-II的水平;采血测定治疗前后空腹血糖(FPG)水平。结果治疗前患者血浆U-II的水平(9.87±1.14)pg/ml,治疗后为(6.89±1.02)pg/ml,治疗前后差异有统计学意义(P<0.01);治疗前后FPG分别为(11.6±1.4)mmol/L和(7.3±2.0)mmol/L,差异有统计学意义(P<0.01);治疗前后氧饱和度(SpO2)分别为(60.8±15.2)%和(83.8±4.7)%,差异有统计学意义(P<0.01);治疗前后呼吸紊乱指数(AHI)分别为(52.2±20.4)次/h和(15.3±3.5)次/h,差异有统计学意义(P<0.01)。结论 U-II的增高可能是T2DM合并DSAHS患者疾病发生、发展的重要因素,通过nCPAP治疗可使患者血浆中血浆U-II水平明显降低,血糖明显下降,SPO2改善,具有显著的临床疗效。Objective To evaluate the clinical effects and significance of serum urotensin II(UII)in patients with type 2 diabetes mellitus and severe obstructive sleep apnea syndrome(OSAS)complicated by hypertension before and after treatment by night continuous positive airway pressure(nCPAP).Methods Total 30 patients with Type 2 diabetes mellitus and severe OSAS complicated with hypertension were enrolled.They were treated with CPAP at night;the contents of serum UII were detected with radioimmunoassay before and after treatment.Meanwhile,saturation of arterial blood oxygen(SpO2)were detected,the levels of blood glucose were detected too.Results The levels of serum UII of the trial group were(9.01±1.04)pg/ml and(7.2±0.8)pg/ml before and after treatment,and the difference between before and after treatment were significant(P<0.005);The levels of blood glucose of the trial group were(11.6±1.4)mmol/L and(7.3±2.0)mmol/L before and after treatment,and the difference between before and after treatment were significant(P<0.001);SpO2 in trial group were(51.22±3.64)%and(75.3±3.6)% before and after treatment,there were significant different between before and after treatment(P<0.001).Conclusion Increase of urotensin II may be an important factor for occurrence and development of type 2 diabetes mellitus and severe OSAS complicated by hypertension,nCPAP can decrease the levels of UII,the levels of fasting glucose and increased SpO2 to treatment these patients.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 2型糖尿病 尾加压素 经鼻持续正压通气 

分 类 号：R587.1[医药卫生—内分泌]