血清松弛素对孕产妇盆底功能影响的研究  

Research on the impact of serum relaxin of maternal pelvic floor function

作　　者：李妍[1] 吕娟[1] 马淑琴[2] 韩淑霞[1] 李际春[1] 

机构地区：[1]宁夏医科大学总医院妇科,宁夏银川750004 [2]宁夏医科大学总医院产科,宁夏银川750004

出　　处：《宁夏医学杂志》2012年第8期736-738,共3页Ningxia Medical Journal

基　　金：宁夏自然科学基金资助项目(NZ10152)

摘　　要：目的测定妊娠和产后不同时期的血清松弛素(RLX)水平,以探讨孕产妇孕期和产后盆底功能变化的机制。方法选取健康孕产妇72例分别于孕晚期、产后6～8周、产后3～6个月作为研究组;无分娩史、无盆底功能障碍性疾病(PFD)史的非妊娠女性20例作为对照组,应用酶联免疫吸附法检测不同时期的血清RLX水平并行PFD问卷调查。结果与产后2组及对照组相比,妊娠晚期RLX水平明显增高(P<0.01),产后2组与对照组的血清RLX水平差异无统计学意义(P=0.913);孕晚期和产后两组有SUI症状者的RLX水平高于无症状者(P<0.05);孕晚期和产后2组的腰骶部酸痛者孕期血清RLX水平明显增高(P<0.05);产后6～8周和3～6个月阴道松弛者孕晚期血清RLX水平均较高。结论血清松弛素的水平与妊娠期及产后盆底功能障碍性疾病的功能改变有关;孕期高水平的血清RLX可作用于盆底胶原组织,可能是孕期和产后盆底障碍性疾病的病理机制之一。Objective To measure the blood relaxin(RLX) level of different period in pregnancy and after labor,to detect the mechanisms of change of pelvic floor dysfunction and the etiopathogenisis of pelvic floor dysfunction(PFD).Methods 72 pregnancies and delivered women were included in the study,they were divided into late pregnancy(groupⅠ),6 to 8 weeks after labor(groupⅡ) and 3 to 6 months after labor(groupⅢ).20 nulliparous and nonfertile women acted as control(control group).Serum concentration of relaxin(RLX) in each group were detected by enzyme-linked immune-sorbent assay;And pelvic floor dysfunction questionnaire were fulfilled.Results Concentration of serum RLX in groupⅠwas significantly higher than that in groupⅡ,group Ⅲ and control group(P<0.001),and there were no significant difference between groupⅡ,group Ⅲ and control(P=0.913).There were statistical relevance of the concentrations of antepartum serum RLX on the symptom of SUI before delivery and early postpartum and the symptom of ache at waist and sacrum before delivery and early postpartum.Conclusion The high level serum of RLX during pregnancy affects the change of pelvic floor collagen,which may be one of the pathomechanisms of PFD.

关 键 词：盆底功能障碍性疾病 血清松弛素 

分 类 号：R713[医药卫生—妇产科学] R714[医药卫生—临床医学]