糖化血红蛋白对糖尿病诊断与治疗监测作用的研究  

Diagnosis and Treatment Monitoring Effect of Glycosylated Hemoglobin on Diabetes Mellitus

作　　者：杜冰洋[1] 关阳 高丽君[3] 

机构地区：[1]吉林市中心医院,吉林吉林132011 [2]吉林中粮生化科技有限责任公司,吉林长春130033 [3]北华大学医学检验学院,吉林吉林132013

出　　处：《北华大学学报（自然科学版）》2012年第4期416-419,共4页Journal of Beihua University（Natural Science）

摘　　要：目的探讨糖化血红蛋白(HbA1c)在糖尿病(DM)诊断和治疗监测中的作用.方法检测91例DM及并发症患者的空腹血糖(FPG)、餐后2 h血糖(2hPG)及HbA1c浓度并进行比较分析.结果 HbA1c频数分布P50对应的HbA1c浓度为5.94%.HbA1c与FPG的相关系数r1=0.489 98,与2hPG的相关系数r2=0.299 95,HbA1c和FPG,2hPG有良好的相关性.HbA1c浓度与DM并发症的相关性分析显示:HbA1c含量越高,DM并发症的发生率也越高.结论 HbA1c对DM诊断有较高的特异性,对预测DM并发症及调整治疗方案有重要意义.Objective To explore the diagnosis and treatment monitoring effect of glycosylated hemoglobin on diabetes mellitus.Method We measured levels of fasting blood glucose(FPG),2-hour postprandial blood glucose(2hPG) and HbA1c for 91 patients of DM with complications so as to study the diagnostic and prognostic significances of glycosylated hemoglobin(HbA1c) in diabetes mellitus(DM).HbA1c concentration frequency distribution in DM was assessed.Results HbA1c concentration at frequency distribution P50 as measured in DM is 5.94%.HbA1c is correlated with FPG and 2hPG,correlation coefficient r1=0.489 98 and r2= 0.299 95,respectively.The relevance analysis of HbA1c concentration and DM complication shows that the higher the HbA1c content is,the higher the incidence rate of DM complication will be.Conclusion HbA1c shows a high specificity for DM diagnosis.It is also implicated in the prediction of DM complication and the adjustment of therapeutic schedule.

关 键 词：糖化血红蛋白 糖尿病并发症 糖尿病诊断 

分 类 号：R587[医药卫生—内分泌]