肝硬化患者凝血功能检测的临床价值  

作　　者：郭德芝[1] 

机构地区：[1]睢县中医院,河南商丘476900

出　　处：《现代诊断与治疗》2012年第5期419-420,共2页Modern Diagnosis and Treatment

摘　　要：目的探讨82例肝硬化患者凝血功能水平及临床应用价值,有助于判断肝损害的程度和预防肝硬化出血倾向等并发症的发生,具有一定的临床意义。方法采用美国Instrumentation Laboratory公司生产的ACL-9000全自动凝血因子分析仪测定82例肝硬化患者的4项凝血指标,包括凝血酶原时间(PT),凝血酶时间(TT),活化部分凝血活酶时间(APTT)和纤维蛋白原(Fib),并与正常对照组作比较。结果肝硬化患者的凝血时间显著延长,4项凝血指标都有程度不同的改变,血浆中的PT,TT,APTT明显延长,Fib却明显下降。并且随着患者疾病的加重,肝功能越差,其相应凝血功能也越差。肝硬化患者凝血功能与正常对照组相比较均有显著差异有统计学意义(P<0.05)。结论肝脏是人体凝血因子主要合成场所,肝硬化患者凝血因子异常可加重疾病发展,出现出血和低凝状态。肝硬化凝血因子的检测,对于预防和治疗肝硬化患者出血具有重要意义,并可指导医生合理用药,改善患者预后。Objective To investigate the effect of coagulation function changes and its clinical values.It helps to diagnose the degree of liver damage and prevent of bleeding.Method To assay prothrombin time(PT),partial thromboplastin time(APTT),thrombin time(TT) and fibrinogen(FIB) with the automated coagulation factor analyzer,ACL-9000,made in America,and control with the normal group.Result PT,APTT and TT of liver cirrhosis group were better than that in control group(P<0.05),and the FIB was distinctly dropped than that in control group(P<0.05).The more severe the disease and the worse liver function.Conclusion The liver is the main place that clotting factors were synthesized.The liver cirrhosis peoples is bleeding and low coagulation status because of the clotting factors being abnormal.It helps doctor give medicine.It has important significance to rescue and treat patients with liver cirrhosis when hemorrhage happened.

关 键 词：肝硬化 凝血功能 临床价值 

分 类 号：R446.11[医药卫生—诊断学]