依帕司他联合高压氧治疗早期糖尿病肾病的临床观察  

Clinical observation on early diabetic nephropathy treated with epalrestat combined hyperbaric oxygen

作　　者：黄锦欢[1] 孙鹏飞[1] 覃灿彬[1] 赖海春[1] 张俊林[1] 

机构地区：[1]玉林市第二人民医院内分泌科,广西玉林537000

出　　处：《四川医学》2012年第11期1977-1979,共3页Sichuan Medical Journal

摘　　要：目的观察依帕司他联合高压氧治疗对早期糖尿病肾病尿白蛋白排泄率的影响。方法将78例早期2型糖尿病肾病患者随机分为治疗组和对照组(各39例),两组均予胰岛素控制血糖,并予依帕司他口服,在此基础上,治疗组加予高压氧治疗,疗程2个月,治疗前后检测血糖、血脂、血液流变学及尿白蛋白排泄率(UAER)。结果治疗前后两组患者血糖、血脂等比较,差异无统计学意义(P>0.05);治疗后两组UAER均下降,但治疗组下降更加显著,两组比较差异有统计学意义(P<0.05)。结论依帕司他联合高压氧可有效降低尿白蛋白排泄率,从而抑制早期糖尿病肾病的进展,疗效优于单纯药物治疗。Objective To observe the effects of combined therapy of epalrestat and hyperbaric oxygen on urinary albumin excretion rate of early diabetic nephropathy.Methods 78 patients with early type 2 diabetic nephropathy were randomly divided into treated group and control group(39 cases each).Control group was treated with insulin and epalrestat,and treated group was treated with insulin,epalrestat and hyperbaric oxygen.The course last 2 months.Blood glucose,lipids,blood rheology and urinary albumin excretion rate(UAER) were detected before and after treatment.Results There were no differences between 2 groups in blood glucose and lipid before or after treatment(P>0.05).UAER was decreased in both groups as compared to before treatment.But there was significantly difference between 2 groups in UAER after treatment(P<0.05).Conclusion The combined therapy of epalrestat and hyperbaric oxygen reduces UAER,thus inhibiting the progress of early diabetic kidney disease,the therapy is more effective than epalrestat alone.

关 键 词：依帕司他 高压氧 尿白蛋白排泄率 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌]